Home / NOP Receptor Antagonists / JTC 801

JTC 801

Catalog #: 2481
3 Citations Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
2481/10
2481/50
JTC 801 | CAS No. 244218-51-7 | NOP Receptor Antagonists
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Description: Selective NOP antagonist

Chemical Name: N-(4-Amino-2-methyl-6-quinolinyl)-2-[(4-ethylphenoxy)methyl]benzamide hydrochloride

Purity: ≥98%

Product Details
Citations (3)
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Biological Activity

JTC 801 is a high affinity, selective NOP receptor antagonist (Ki = 8.2 nM). Displays approximately 12.5-, 129- and 1055-fold selectivity over human μ-, κ- and δ-opioid receptors respectively. Exhibits anti-nociceptive effects in acute pain models in vivo. Orally active.

Technical Data

M.Wt:
447.96
Formula:
C26H25N3O2.HCl
Solubility:
Soluble to 100 mM in DMSO and to 20 mM in ethanol
Purity:
≥98%
Storage:
Desiccate at RT
CAS No:
244218-51-7

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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Citations for JTC 801

The citations listed below are publications that use Tocris products. Selected citations for JTC 801 include:

3 Citations: Showing 1 - 3

  1. Nociceptin/orphanin FQ peptide receptor antagonist JTC-801 reverses pain and anxiety symptoms in a rat model of post-traumatic stress disorder.
    Authors: Zhang Et al.
    PLoS One  2015;172:571
  2. Role of nociceptin/orphanin FQ and NOP receptors in the response to acute and repeated restraint stress in rats.
    Authors: Delaney Et al.
    J Neuroendocrinol  2012;24:1527
  3. Modulation of silent and constitutively active nociceptin/orphanin FQ receptors by potent receptor antagonists and Na+ ions in rat sympathetic neurons.
    Authors: Mahmoud Et al.
    Mol Pharmacol  2010;77:804

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