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JZP 361

Catalog #: 5851 Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
5851/10
5851/50
JZP 361 | CAS No. 1680193-80-9 | Monoacylglycerol Lipase Inhibitors
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Description: Potent and selective reversible MAGL inhibitor

Chemical Name: [4-(8-Chloro-5,6-dihydro-11H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-ylidene)-1-piperidinyl](1H-1,2,4-triazol-1-yl)methanone

Purity: ≥99%

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Biological Activity

JZP 361 is a potent and selective reversible MAGL inhibitor (IC50 = 46 nM). Exhibits 35-fold and 150-fold higher selectivity over human FAAH and ABHD6, respectively (IC50 values are 1.79 and 7.24 μM, respectively). Displays affinity for H1 receptors (pA2 = 6.81). Exhibits no activity at cannabinoid receptors at 10 μM.

Technical Data

M.Wt:
405.88
Formula:
C22H20ClN5O
Solubility:
Soluble to 100 mM in DMSO and to 20 mM in ethanol
Purity:
≥99%
Storage:
Store at +4°C
CAS No:
1680193-80-9

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. Loratadine analogues as MAGL inhibitors.
    Patel et al.
    Bioorg.Med.Chem.Lett., 2015;25:1436

Product Datasheets

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