K 22
Chemical Name: N-[(1Z)-1-[[4-(4-Bromophenyl)-4-hydroxy-1-piperidinyl]carbonyl]-2-phenylethenyl]benzamide
Purity: ≥98%
Biological Activity
K 22 is a viral RNA synthesis inhibitor; targets membrane-bound coronaviral RNA replication by inhibiting double membrane vesicle (DMV) formation. Inhibits HCoV-229E infection of MRC-5 cells in a plaque forming assay (IC50 = 0.7 μM). Also inhibits HCoV-229E and MERS-CoV replication in human airway epithelia cultures.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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Targeting membrane-bound viral RNA synthesis reveals potent inhibition of diverse coronaviruses including the middle East respiratory syndrome virus.
Lundin et al.
PLoS Pathog., 2014;10:e1004166
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