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KC 12291 hydrochloride

Catalog #: 3251 Datasheet / COA / SDS

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3251 has been discontinued.
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KC 12291 hydrochloride | CAS No. 181936-98-1 | Voltage-gated Sodium Channel Blockers
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Description: Orally active atypical Na+ channel blocker; cardioprotective

Chemical Name: 3,4-Dimethoxy-N-methyl-N-[3-[(5-phenyl-1,2,4-thiadiazol-3-yl)oxy]propyl]benzeneethanamine hydrochloride

Purity: ≥97%

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Biological Activity

KC 12291 hydrochloride is an orally active atypical voltage-gated sodium channel blocker. Inhibits sustained sodium currents (INaL) and prevents diastolic contracture in isolated atria in vitro (IC50 values are 9.6 and 0.55 - 0.79 μM respectively). Displays anti-ischemic, bradycardic and cardioprotective activity in vivo.

Technical Data

M.Wt:
449.99
Formula:
C22H27N3O3S.HCl
Solubility:
Soluble to 25 mM in water and to 50 mM in DMSO
Purity:
≥97%
Storage:
Desiccate at +4°C
CAS No:
181936-98-1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. Anti-ischemic compound KC 12291 prevents diastolic contracture in isolated atria by blockade of voltage-gated sodium channels.
    Tamareille et al.
    J.Cardiovasc.Pharmacol., 2002;40:346
  2. KC 12291: an atypical sodium channel blocker with myocardial antiischemic properties.
    John et al.
    Cardiovasc.Drug Rev., 2004;22:17
  3. Pharmacological characterisation of sodium channels in sinoatrial node pacemaking in the rat heart.
    Letienne et al.
    Eur.J.Pharmacol., 2006;530:243
  4. Cardioprotective actions of KC 12291.
    Decking et al.
    Naunyn-Schmied.Arch.Pharmacol., 1998;358:547

Product Datasheets

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