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KC7F2

Catalog #: 4324
2 Citations Datasheet / COA / SDS
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4324/50
KC7F2 | CAS No. 927822-86-4 | HIF Inhibitors
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Description: HIF-1α inhibitor; down-regulates HIF-1α protein synthesis

Chemical Name: N,N'-(Dithiodi-2,1-ethanediyl)bis[2,5-dichlorobenzenesulfonamide

Purity: ≥98%

Product Details
Citations (2)
Reviews
Biological Activity Technical Data Background Product Datasheets Calculators

Biological Activity

KC7F2 is an inhibitor of HIF-1α. Thought to act via down-regulation of HIF-1α protein synthesis; reduces phosphorylation of eIF4E binding protein 1 (4EBP1) and p70 S6K in hypoxic conditions. Also blocks hypoxia-induced HIF-1α accumulation in a range of human cancer cell lines. Inhibits the expression of HIF target genes, such as carbonic anhydrase IX and MMP2.

Technical Data

M.Wt:
570.38
Formula:
C16H16Cl4N2O4S4
Solubility:
Soluble to 100 mM in DMSO
Purity:
≥98%
Storage:
Store at -20°C
CAS No:
927822-86-4

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. Gastrointestinal cancer cells treatment with bevacizumab activates a VEGF autoregulatory mechanism involving telomerase catalytic subunit hTERT via PI3K-AKT, HIF-1? and VEGF receptors
    N Mahfouz, R Tahtouh, N Alaaeddine, J El Hajj, R Sarkis, R Hachem, I Raad, G Hilal
    PLoS ONE, 2017;12(6):e0179202.
  2. Hypoxia induces pulmonary fibroblast proliferation through NFAT signaling
    LK Senavirath, C Huang, X Yang, MC Munteanu, R Sathiaseel, D Xu, CA Henke, L Liu
    Sci Rep, 2018;8(1):2709.
  3. Hypoxia increases neutrophil-driven matrix destruction after exposure to Mycobacterium tuberculosis
    CWM Ong, K Fox, A Ettorre, PT Elkington, JS Friedland
    Sci Rep, 2018;8(1):11475.
  4. Inhibiting the hypoxia response for cancer therapy: the new kid on the block.
    Koh et al.
    Clin.Cancer Res., 2009;15:5945
  5. Identification of a novel small molecule HIF-1α translation inhibitor.
    Narita et al.
    Clin.Cancer Res., 2009;15:6128

Product Datasheets

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Citations for KC7F2

The citations listed below are publications that use Tocris products. Selected citations for KC7F2 include:

2 Citations: Showing 1 - 2

  1. LXR Activation Induces a Proinflammatory Trained Innate Immunity-Phenotype in Human Monocytes.
    Authors: Hannes M Et al.
    Front Immunol  2020;11:353
  2. Lactate preconditioning promotes a HIF-1α-mediated metabolic shift from OXPHOS to glycolysis in normal human diploid fibroblasts.
    Authors: Dean H Et al.
    Sci Rep  2020;10:8388

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