Home / 5-HT2A Receptor Antagonists / Ketanserin tartrate

Ketanserin tartrate

Catalog #: 0908
23 Citations Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
0908/50
0908/250
Ketanserin tartrate | CAS No. 83846-83-7 | 5-HT2A Receptor Antagonists
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Description: Selective 5-HT2A antagonist. Also antagonist at 5-HT1D
Alternative Names: R 41 468

Chemical Name: 3-[2-[4-(4-Fluorobenzoyl)-1-piperidinyl]ethyl]-2,4[1H,3H]-quinazolinedione tartrate

Purity: ≥97%

Product Details
Citations (23)
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Biological Activity

Ketanserin tartrate is a selective 5-HT2A serotonin receptor antagonist; can also be used to discriminate between 5-HT1D and 5-HT1B receptor subtypes.

Technical Data

M.Wt:
545.52
Formula:
C22H22FN3O3.C4H6O6
Solubility:
Soluble to 10 mM in water
Purity:
≥97%
Storage:
Store at RT
CAS No:
83846-83-7

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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Citations for Ketanserin tartrate

The citations listed below are publications that use Tocris products. Selected citations for Ketanserin tartrate include:

23 Citations: Showing 1 - 10

  1. High and hyper: fentanyl induces psychomotor side-effects in healthy pigs.
    Authors: Digranes Et al.
    Animals  2023;13:1671
  2. Potentiation of the glycine response by serotonin on the substantia gelatinosa neurons of the trigeminal subnucleus caudalis in mice.
    Authors: Nguyen Et al.
    Korean J Physiol Pharmacol  2019;23:271
  3. Maternal Regulation of Pups' Cortical Activity: Role of Serotonergic Signaling.
    Authors: Courtiol Et al.
    Eneuro  2018;5
  4. Initiation of Behavioral Response to Antidepressants by Cholecystokinin Neurons of the Dentate Gyrus.
    Authors: Medrihan Et al.
    Neuron  2017;95:564
  5. Monoaminergic modulation of GABAergic transmission onto cerebellar globular cells.
    Authors: Hirono
    Neuropharmacology  2017;118:79
  6. Potentiation of 5-methoxy-N,N-dimethyltryptamine-induced hyperthermia by harmaline and the involvement of activation of 5-HT1A and 5-HT2A receptors.
    Authors: Jiang Et al.
    Br J Pharmacol  2015;89:342
  7. Serotonin-2C receptor agonists decrease potassium-stimulated GABA release in the nucleus accumbens.
    Authors: Kasper Et al.
    Neuropharmacology  2015;69:78
  8. Behavioral and neurochemical changes in mesostriatal DArgic regions of the rat after chronic administration of the cannabinoid receptor agonist WIN55,212-2.
    Authors: Fanarioti Et al.
    Synapse  2015;18
  9. A xanthine-derivative K(+)-channel opener protects against serotonin-induced cardiomyocyte hypertrophy via the modulation of protein kinases.
    Authors: Kuo Et al.
    Int J Biol Sci  2014;10:64
  10. Neuroprotection through excitability and mTOR required in ALS motoneurons to delay disease and extend survival.
    Authors: Saxena Et al.
    Neuron  2013;80:80
  11. Cerebral markers of the serotonergic system in rat models of obesity and after Roux-en-Y gastric bypass.
    Authors: Ratner Et al.
    Neuron  2012;20:2133
  12. Gene therapy by targeted adenovirus-mediated knockdown of pulmonary endothelial Tph1 attenuates hypoxia-induced pulmonary hypertension.
    Authors: Morecroft Et al.
    Cereb Cortex  2012;20:1516
  13. Serotonin, via HTR2 receptors, excites neurons in a cortical-like premotor nucleus necessary for song learning and production.
    Authors: Wood Et al.
    J Neurosci  2011;31:13808
  14. Serotonin receptor activity is necessary for olfactory learning and memory in Drosophila melanogaster.
    Authors: Johnson Et al.
    Neuroscience  2011;192:372
  15. Vasoconstrictor potential of coronary aspirate from patients undergoing stenting of saphenous vein aortocoronary bypass grafts and its pharmacological attenuation.
    Authors: Kleinbongard Et al.
    Circ Res  2011;108:344
  16. In vivo effects of a combined 5-HT1B receptor/SERT antagonist in experimental pulmonary hypertension.
    Authors: Morecroft Et al.
    Int J Neuropsychopharmacol  2010;85:593
  17. Repeated cocaine administration decreases 5-HT(2A) receptor-mediated serotonergic enhancement of synaptic activity in rat medial prefrontal cortex.
    Authors: Huang Et al.
    Neuropsychopharmacology  2009;34:1979
  18. Enriched expression of serotonin 1B and 2A receptor genes in macaque visual cortex and their bidirectional modulatory effects on neuronal responses.
    Authors: Watakabe Et al.
    Br J Pharmacol  2009;19:1915
  19. Investigation of the role of 5-HT2 receptor subtypes in the control of the bladder and the urethra in the anaesthetized female rat.
    Authors: Mbaki
    Br J Pharmacol  2008;155:343
  20. Hallucinogens recruit specific cortical 5-HT(2A) receptor-mediated signaling pathways to affect behavior.
    Authors: González-Maeso Et al.
    Mol Ther  2007;53:439
  21. Stimulation of glycogen synthesis and inactivation of phosphorylase in hepatocytes by serotonergic mechanisms, and counter-regulation by atypical antipsychotic drugs.
    Authors: Hampson Et al.
    Diabetologia  2007;50:1743
  22. Serotonergic and nonserotonergic dorsal raphe neurons are pharmacologically and electrophysiologically heterogeneous.
    Authors: Marinelli Et al.
    J Neurophysiol  2004;92:3532
  23. 5-hydroxytryptamine receptors mediating contraction in human small muscular pulmonary arteries: importance of the 5-HT1B receptor.
    Authors: Morecroft Et al.
    Obesity (Silver Spring)  1999;128:730

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