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KI-7

Catalog #: 6787 Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
6787/10
6787/50
KI-7 | CAS No. 1489263-00-4 | Adenosine A2b Receptor Agonists
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Description: Positive allosteric modulator of A2B receptors

Chemical Name: α-Oxo-N-phenyl-1-(phenylmethyl)-1H-indole-3-acetamide

Purity: ≥98%

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Biological Activity

KI-7 is an adenosine A2B receptor positive allosteric modulator. Potentiates the NECA (Cat. No. 1691) -induced increase in cAMP production in CHO cells expressing A2B receptors. Also potentiates the effects of NECA and the A2B receptor agonist BAY 60-6583 (Cat. No. 4472) in mediating osteoblast differentiation from MSCs in vitro.

Technical Data

M.Wt:
354.4
Formula:
C23H18N2O2
Solubility:
Soluble to 50 mM in DMSO
Purity:
≥98%
Storage:
Store at +4°C
CAS No:
1489263-00-4

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. Osteoblast differentiation and survival: A role for A2B adenosine receptor allosteric modulators.
    Trincavelli et al.
    Biochim.Biophys.Acta, 2014;1843:2957
  2. Allosteric modulators of human A2B adenosine receptor.
    Trincavelli et al.
    Biochim.Biophys.Acta, 2014;1840:1194

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