Home / Hydrolase Inhibitors / KLH 45

KLH 45

Catalog #: 5865 Datasheet / COA / SDS

Discontinued Product

5865 has been discontinued.
View all Hydrolase Inhibitors products.
KLH 45 | CAS No. 1632236-44-2 | Hydrolase Inhibitors
1 Image
Description: Potent DDHD2 inhibitor

Chemical Name: N-Cyclohexyl-N-(2-phenylethyl)-4-[4-(trifluoromethoxy)phenyl]-2H-1,2,3-triazole-2-carboxamide

Purity: ≥98%

Product Details
Reviews
Biological Activity Technical Data Additional Information Background Product Datasheets Calculators

Biological Activity

KLH 45 is a potent DDHD2 inhibitor (IC50 = 1.3 nM). Selective for DDHD2 over 40 other serine hydrolases, but does exhibit cross-reactivity with ABHD6. Active in vivo. Increases brain triacylglycerol levels in mice.

Technical Data

M.Wt:
458.48
Formula:
C24H25F3N4O2
Solubility:
Soluble to 100 mM in DMSO and to 100 mM in ethanol
Purity:
≥98%
Storage:
Store at -20°C
CAS No:
1632236-44-2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Additional Information

Licensing Caveats:
Sold under license from The Scripps Research Institute

Background References

  1. The hereditary spastic paraplegia-related enzyme DDHD2 is a principal brain triglyceride lipase.
    Inloes et al.
    Proc.Natl.Acad.Sci.U.S.A., 2014;111:14924

Product Datasheets

Reconstitution Calculator
Molarity Calculator

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Molarity Calculator

=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

FAQs

No product specific FAQs exist for this product, however you may

View all Small Molecule FAQs

Reviews for KLH 45

There are currently no reviews for this product. Be the first to review KLH 45 and earn rewards!

Have you used KLH 45?

Submit a review and receive an Amazon gift card.

$25/€18/£15/$25CAN/¥75 Yuan/¥2500 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review
Tocris Bioscience is the leading supplier of novel and exclusive tools for life science research with over 30 years' experience in the industry. Tocris is a Bio-Techne brand.