KT 5823
Chemical Name: (9S,10R,12R)-2,3,9,10,11,12-Hexahydro-10-methoxy-2,9-dimethyl-1-oxo-9,12-epoxy-1H-diindolo[1,2,3-fg:3',2',1'-kl]pyrrolo[3,4-i][1,6]benzodiazocine-10-carboxylic acid, methyl ester
Purity: ≥95%
Biological Activity
KT 5823 is a selective inhibitor of protein kinase G (Ki values are 0.23, 4 and > 10 μM for inhibition of PKG, PKC and PKA respectively). Inhibits SNP-stimulated PKG activity with an IC50 of 60 nM in dispersed smooth muscle cells and has little effect on PKA activity at concentrations of up to 10 μM.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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Inhibitory Effects of Dopamine Receptor D1 Agonist on Mammary Tumor and Bone Metastasis
K Minami, S Liu, Y Liu, A Chen, Q Wan, S Na, BY Li, N Matsuura, M Koizumi, Y Yin, L Gan, A Xu, J Li, H Nakshatri, H Yokota
Sci Rep, 2017;7(0):45686. -
Intracellular nitric oxide mediates neuroproliferative effect of neuropeptide y on postnatal hippocampal precursor cells.
Cheung A, Newland PL, Zaben M
J. Biol. Chem., 2012;287(24):20187-96. -
Multiple kinase arrest points in the G1 phase of nontransformed mammalian cells are absent in transformed cells.
Gadbois et al.
Proc.Natl.Acad.Sci.U.S.A., 1992;89:8626 -
Interaction of cA-kinase and cG-kinase in mediating relaxation of dispersed smooth muscle cells.
Murthy and Makhlouf
Am.J.Physiol., 1995;268:C171 -
Functional analysis of cGMP-dependent protein kinases I and II as mediators of NO/cGMP effects.
Smolenski et al.
Naunyn Schmiedebergs Arch.Pharmacol., 1998;358:134
Product Datasheets
Citations for KT 5823
The citations listed below are publications that use Tocris products. Selected citations for KT 5823 include:
6 Citations: Showing 1 - 6
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Nitric oxide suppression by secreted frizzled-related protein 2 drives retinoblastoma
Authors: Jayabal Et al.
Cell Rep 2023;42:112103
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Secreted Amyloid Precursor Protein-Alpha Promotes Arc Protein Synthesis in Hippocampal Neurons.
Authors: Livingstone Et al.
Front Mol Neurosci 2019;12:198
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Differential activation of natriuretic peptide receptors modulates cardiomyocyte proliferation during development.
Authors: Becker Et al.
Development 2014;141:335
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A xanthine-derivative K(+)-channel opener protects against serotonin-induced cardiomyocyte hypertrophy via the modulation of protein kinases.
Authors: Kuo Et al.
Int J Biol Sci 2014;10:64
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The bitter taste receptor (TAS2R) agonists denatonium and chloroquine display distinct patterns of relaxation of the guinea pig trachea.
Authors: Pulkkinen Et al.
Am J Physiol Lung Cell Mol Physiol 2012;303:L956
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Hyperlipidaemia induced by a high-cholesterol diet leads to the deterioration of guanosine-3',5'-cyclic monophosphate/protein kinase G-dependent cardioprotection in rats.
Authors: Giricz Et al.
J Neurosci 2009;158:1495
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