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KY 02111

Catalog #: 4731
2 Citations Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
4731/5
4731/25
KY 02111 | CAS No. 1118807-13-8 | Compounds for Stem Cell Differentiation
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Description: Inhibits canonical Wnt signaling. Promotes differentiation of human ESCs and iPSCs into cardiomyocytes

Chemical Name: N-(6-Chloro-2-benzothiazolyl)-3,4-dimethoxybenzenepropanamide

Purity: ≥98%

Product Details
Citations (2)
Reviews
Biological Activity Technical Data Background Product Datasheets Calculators

Biological Activity

KY 02111 promotes differentiation of human ESCs and iPSCs into cardiomyocytes when used after day three in culture; differentiation efficiency increases when used after initial culture with CHIR 99021 (Cat. No. 4423). Induces downregulation of Wnt signaling target genes; inhibits canonical Wnt signaling in a manner distinct from other known Wnt inhibitors.

Technical Data

M.Wt:
376.86
Formula:
C18H17ClN2O3S
Solubility:
Soluble to 50 mM in DMSO
Purity:
≥98%
Storage:
Store at +4°C
CAS No:
1118807-13-8

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. Isogenic Pairs of hiPSC-CMs with Hypertrophic Cardiomyopathy/LVNC-Associated ACTC1 E99K Mutation Unveil Differential Functional Deficits
    JGW Smith, T Owen, JR Bhagwan, D Mosqueira, E Scott, I Mannhardt, A Patel, R Barriales-, L Monserrat, A Hansen, T Eschenhage, SE Harding, S Marston, C Denning
    Stem Cell Reports, 2018;0(0):.
  2. A small molecule that promotes cardiac differentiation of human pluripotent stem cells under defined, cytokine- and xeno-free conditions.
    Minami et al.
    Cell Rep., 2012;2:1448

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Citations for KY 02111

The citations listed below are publications that use Tocris products. Selected citations for KY 02111 include:

2 Citations: Showing 1 - 2

  1. Variable expression and silencing of CRISPR-Cas9 targeted transgenes identifies the AAVS1 locus as not an entirely safe harbour.
    Authors: Chris Et al.
    F1000Res  2020;8:1911
  2. Rapamycin and CHIR99021 coordinate robust cardiomyocyte differentiation from human pluripotent stem cells via reducing p53-dependent apoptosis.
    Authors: Qui Et al.
    J.Am.Heart Assoc.  2017;6:e005295

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