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L-651,582

Catalog #: 3086 Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
3086/10
3086/50
L-651,582 | CAS No. 99519-84-3 | Non-selective Cav Blockers
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Description: Non-selective Ca2+ channel blocker
Alternative Names: Carboxyamidotriazole

Chemical Name: 5-Amino-1-[[3,5-dichloro-4-(4-chlorobenzoyl)phenyl]methyl]-1H-1,2,3-triazole-4-carboxamide

Purity: ≥98%

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Biological Activity

L-651,582 is an orally active Ca2+ channel blocker; inhibits K+- and carbachol-stimulated Ca2+ influx (IC50 values are 500 and 935 nM respectively). Exhibits antiproliferative, antiangiogenic and antimetastatic activity in vivo and displays selectivity towards numerous mismatch repair-deficient tumor cell lines in vitro.

Technical Data

M.Wt:
424.67
Formula:
C17H12Cl3N5O2
Solubility:
Soluble to 100 mM in DMSO
Purity:
≥98%
Storage:
Store at +4°C
CAS No:
99519-84-3

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. The inhibition of receptor-mediated and voltage-dependent calcium entry by the antiproliferative L-651,582
    Hupe et al.
    J.Biol.Chem., 1991;266:10136
  2. Selective sensitivity to carboxyamidotriazole by human tumor cell lines with DNA mismatch repair deficiency.
    Yang et al.
    Int.J.Cancer., 2008;123:258
  3. The antiproliferative and antimetastatic compound L651582 inhibits muscarinic acetylcholine receptor-stimulated calcium influx and arachidonic acid release.
    Felder et al.
    J.Pharm.Exp.Ther., 1991;257:967

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