L-741,742 hydrochloride
Chemical Name: 5-(4-Chlorophenyl)-4-methyl-3-(1-(2-phenylethyl)piperidin-4-yl)isoxazole hydrochloride
Purity: ≥98%
Biological Activity
L-741,742 hydrochloride is a potent and highly selective D4 dopamine receptor antagonist, with Ki values of > 1700, 770 and 3.5 nM at cloned human D2, D3 and D4 receptors.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Additional Information
Background References
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High-throughput genotoxicity assay identifies antioxidants as inducers of DNA damage response and cell death.
Fox JT, Sakamuru S, Huang R
Proc. Natl. Acad. Sci. U.S.A., 2012;109(14):5423-8. -
5-(4-Chlorophenyl)-4-methyl-3-(1-(2-phenylethyl)piperidin-4-yl)isoxazole: a potent, selective antagonist at human cloned DA D4 receptors.
Rowley et al.
J. Med. Chem., 1996;39:1943 -
4-Heterocyclylpiperidines as selective high-affinity ligands at the human DA D4 receptor.
Rowley et al.
J.Med.Chem., 1997;40:2374
Product Datasheets
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Citations for L-741,742 hydrochloride
The citations listed below are publications that use Tocris products. Selected citations for L-741,742 hydrochloride include:
3 Citations: Showing 1 - 3
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Inhibition of Dopamine Receptor D4 Impedes Autophagic Flux, Proliferation, and Survival of Glioblastoma Stem Cells.
Authors: Dolma Et al.
Cancer Cell 2016;29:829
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NE activates DA D4 receptors in the rat lateral habenula.
Authors: Root Et al.
J Neurosci 2015;35:3460
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Prototypical antipsychotic drugs protect hippocampal neuronal cultures against cell death induced by growth medium deprivation.
Authors: Bastianetto Et al.
BMC Neurosci 2006;7:28
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