Home / Adrenergic beta-3 Receptor Agonists / L-755,507

L-755,507

Catalog #: 2197
6 Citations Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
2197/10
2197/50
L-755,507 | CAS No. 159182-43-1 | Adrenergic beta-3 Receptor Agonists
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Description: Very potent and selective β3 partial agonist

Chemical Name: 4-[[(Hexylamino)carbonyl]amino]-N-[4-[2-[[(2S)-2-hydroxy-3-(4-hydroxyphenoxy)propyl]amino]ethyl]phenyl]-benzenesulfonamide

Purity: ≥98%

Product Details
Citations (6)
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Biological Activity

L-755,507 is a potent β3-adrenergic receptor partial agonist > 1000-fold selective over β1- and β2-adrenoceptors (EC50 values are 0.43, 580 and > 10000 nM for activation of cloned human β3-, β1- and β2-adrenoceptors respectively). Stimulates lipolysis in rhesus adipocytes in vitro (EC50 = 3.9 nM). Enhances CRISPR-mediated homology-directed repair (HDR) efficiency 2-3-fold for large fragments and ~9-fold for point mutations, in human induced pluripotent stem cells (iPSCs).

Technical Data

M.Wt:
584.73
Formula:
C30H40N4O6S
Solubility:
Soluble to 100 mM in DMSO and to 100 mM in ethanol
Purity:
≥98%
Storage:
Store at +4°C
CAS No:
159182-43-1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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Citations for L-755,507

The citations listed below are publications that use Tocris products. Selected citations for L-755,507 include:

6 Citations: Showing 1 - 6

  1. Targeting repair pathways with small molecules increases precise genome editing in pluripotent stem cells.
    Authors: Riesenberg and Maricic
    Nat Commun  2018;9:2164
  2. Highly Efficient and Versatile Plasmid-Based Gene Editing in Primary T Cells.
    Authors: Kornete Et al.
    J Immunol  2018;200:2489
  3. Nuclear domain 'knock-in' screen for the evaluation and identification of small molecule enhancers of CRISPR-based genome editing.
    Authors: Pinder Et al.
    Nucleic Acids Res  2015;43:9379
  4. Do β3-adrenergic receptors play a role in guinea pig detrusor smooth muscle excitability and contractility?.
    Authors: Afeli Et al.
    Am J Physiol Renal Physiol  2012;302:F251
  5. Promiscuous aggregate-based inhibitors promote enzyme unfolding.
    Authors: Coan Et al.
    J Med Chem  2009;52:2067
  6. Stoichiometry and physical chemistry of promiscuous aggregate-based inhibitors.
    Authors: Coan and Shoichet
    J Am Chem Soc  2008;130:9606

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