L-798,106
Chemical Name: N-[(5-Bromo-2-methoxyphenyl)sulfonyl]-3-[2-(2-naphthalenylmethyl)phenyl]-2-propenamide
Purity: ≥99%
Biological Activity
L-798,106 is a potent and highly selective prostanoid EP3 receptor antagonist (Ki values are 0.3, 916, > 5000 and > 5000 nM at EP3, EP4, EP1 and EP2 respectively). Attenuates sulprostone-induced inhibition of EFS-evoked twitch and contractile responses in vivo.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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TREM-1 is induced in tumor associated macrophages by cyclo-oxygenase pathway in human non-small cell lung cancer.
Yuan, Zhihong, Mehta, Hiren J, Mohammed, Kamal, Nasreen, Najmunis, Roman, Robert, Brantly, Mark, Sadikot, Ruxana T
PLoS ONE, 2014;9(5):e94241. -
Human mesenchymal stem/stromal cells cultured as spheroids are self-activated to produce prostaglandin E2 that directs stimulated macrophages into an anti-inflammatory phenotype.
Ylostalo J, Bartosh T, Coble K, Prockop D
Stem Cells, 2012;30(10):2283-96. -
Up-regulation of EP2 and EP3 receptors in human tolerogenic dendritic cells boost the immunosuppressive activity of PGE2
G Flórez-Gra, R Cabezón, KJE Borgman, C España, JJ Lozano, MF Garcia-Par, D Benítez-Ri
J. Leukoc. Biol., 2017;0(0):. -
Structure-activity relationships of cinnamic acylsulfonamide analogues on human EP3 prostanoid receptor.
Juteau et al.
Bioorg.Med.Chem., 2001;9:1977 -
E-ring 8-isoprostanes inhibit ACh release from parasympathetic nerves innervating guinea-pig trachea through agonism of prostanoid receptors of the EP3-subtype.
Clarke et al.
Br.J.Pharmacol., 2004;141:600 -
Activation of prostaglandin EP receptors by lubipro. in rat and human stomach and colon.
Bassil et al.
Br.J.Pharmacol., 2008;154:126
Product Datasheets
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Citations for L-798,106
The citations listed below are publications that use Tocris products. Selected citations for L-798,106 include:
7 Citations: Showing 1 - 7
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Prostaglandin receptor EP3 regulates cell proliferation and migration with impact on survival of endometrial cancer patients.
Authors: Zhu
Oncotarget 2018;9(1):982
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Prostaglandin E2 receptor 3 signaling is induced in placentas with unexplained recurrent pregnancy losses.
Authors: Ye Et al.
Endocr Connect 2018;7:749
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Autocrine-paracrine prostaglandin E2 signaling restricts TLR4 internalization and TRIF signaling.
Authors: Perkins Et al.
Nat.Immunol. 2018;19:1309
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Exposure to 50 Hz magnetic field modulates GABAA currents in cerebellar granule neurons through an EP receptor-mediated PKC pathway.
Authors: Yang Et al.
J Cell Mol Med 2015;19:2413
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Effects of lipoic acid on lipolysis in 3T3-L1 adipocytes.
Authors: Fernández-Galilea Et al.
J Lipid Res 2012;53:2296
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Castor oil induces laxation and uterus contraction via ricinoleic acid activating prostaglandin EP3 receptors.
Authors: Tunaru Et al.
Cell Commun Signal 2012;109:9179
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Protection of protease-activated receptor 2 mediated vasodilatation against angiotensin II-induced vascular dysfunction in mice.
Authors: Chia Et al.
BMC Pharmacol 2011;11:10
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