Laurdan
Chemical Name: 1-[6-(Dimethylamino)-2-naphthalenyl]-1-dodecanone
Purity: ≥95%
Biological Activity
Key information: Laurdan is a polarity sensitive fluorescent probe for imaging lipid rafts in membranes (also known as lipid microdomains). Suitable for live and fixed cells as well as in whole tissues imaging with multiphoton microscopy.Used for: imaging lipid raft and cell membrane investigations.
Application: fluorescence microscope. Suitable for use with generalized polarization (GP) imaging and scanning fluorescence correlation spectroscopy (FCS).
Properties and Photophysical Data: When Laurdan is incorporated into membranes, its fluorescence spectra is sensitive to the physical state of the surrounding phospholipids. Excitation and emission maxima (λ) are 366 nm and 497 nm, respectively; quantum yield = 0.61; extinction coefficient = 19,500 M-1cm-1. In gel and liquid phase membranes, excitation and emission maxima (λ) are 440 nm and 490 nm, respectively.
Optical Data for Laurdan
| Emission Color | Blue |
|---|---|
| λabs | 366 nm |
| λem | 497 nm |
| Extinction Coefficient (ε) | 19500 M-1cm-1 |
| Quantum Yield (φ) | 0.61 |
| Application | Polarity Sensitive Fluorescent Probe for Lipid Raft and Cell Membrane Investigations |
| Alternative For | C-Laurdan, Di-4-ANEPPDHQ |
Plan Your Experiments
Use our spectra viewer to interactively plan your experiments, assessing multiplexing options. View the excitation and emission spectra for our fluorescent dye range and other commonly used dyes.
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Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
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