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Liproxstatin-1 hydrochloride

Catalog #: 6113 Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
6113/25
6113/5
Liproxstatin-1 hydrochloride | CAS No. 2250025-95-5 | Ferroptosis Inhibitors
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Description: Potent ferroptosis inhibitor

Chemical Name: N-[(3-Chlorophenyl)methyl]spiro[piperidine-4,2'(1'H)-quinoxalin]-3'-amine hydrochloride

Purity: ≥98%

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Biological Activity

Liproxstatin-1 hydrochloride is a potent ferroptosis inhibitor (IC50 = 22 nM). Protects human renal proximal tubule cells from 1S,3R-RSL3 (Cat.No. 6118) -induced cell death in vitro. Inhibits acute renal failure and prolongs survival in Gpx4 knockdown mice. Also mitigates tissue damage in an in vivo hepatic ischemia/reperfusion model.

Technical Data

M.Wt:
377.31
Formula:
C19H21ClN4.HCl
Solubility:
Soluble to 100 mM in DMSO
Purity:
≥98%
Storage:
Store at -20°C
CAS No:
2250025-95-5

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. Inactivation of the ferroptosis regulator Gpx4 triggers acute renal failure in mice.
    Friedmann Angeli et al.
    Nat.Cell.Biol., 2014;16:1180

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