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LM 22A4

Catalog #: 4607
2 Citations Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
4607/5
4607/25
LM 22A4 | CAS No. 37988-18-4 | Trk Receptor Agonists
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Description: Potent TrkB agonist

Chemical Name: N,N',N''Tris(2-hydroxyethyl)-1,3,5-benzenetricarboxamide

Purity: ≥98%

Product Details
Citations (2)
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Biological Activity Technical Data Background Product Datasheets Calculators

Biological Activity

LM 22A4 is a potent tropomyosin-related kinase B (TrkB) agonist. Induces activation of Trk, Akt and ERK in mouse hippocampus and striatum and exhibits neurotrophic activity. Reverses deficits in motor task learning in mice following traumatic brain injury; restores respiratory function in a rat model of Rett syndrome.

Technical Data

M.Wt:
339.34
Formula:
C15H21N3O6
Solubility:
Soluble to 100 mM in DMSO and to 100 mM in water
Purity:
≥98%
Storage:
Store at +4°C
CAS No:
37988-18-4

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. REST suppression mediates neural conversion of adult human fibroblasts via microRNA-dependent and -independent pathways
    J Drouin-Oue, S Lau, PL Brattås, D Rylander O, K Pircs, DA Grassi, LM Collins, R Vuono, A Andersson, G Westergren, C Graff, L Minthon, H Toresson, RA Barker, J Jakobsson, M Parmar
    EMBO Mol Med, 2017;9(8):1117-1131.
  2. A TrkB small molecule partial agonist rescues TrkB phosphorylation deficits and improves respiratory function in a mouse model of Rett syndrome.
    Schmid et al.
    J.Neurosci., 2012;32:1803
  3. Small molecule BDNF mimetics activate TrkB signaling and prevent neuronal degeneration in rodents.
    Massa et al.
    J.Clin.Invest., 2010;120:1774
  4. Direct Conversion of Human Stem Cell-Derived Glial Progenitor Cells into GABAergic Interneurons
    J Giacomoni, A Bruzelius, CA Stamouli, D Rylander O
    Cells, 2020;9(11):.

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Citations for LM 22A4

The citations listed below are publications that use Tocris products. Selected citations for LM 22A4 include:

2 Citations: Showing 1 - 2

  1. Huntington's Disease Patient-Derived Astrocytes Display Electrophysiological Impairments and Reduced Neuronal Support.
    Authors: Garcia Et al.
    Front Neurosci  2019;13:669
  2. Brain-derived neurotrophic factor enhances cholinergic contraction of longitudinal muscle of rabbit intestine via activation of phospholipase C.
    Authors: Al-Qudah Et al.
    Am J Physiol Gastrointest Liver Physiol  2014;306:G328

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