LNT 1
Chemical Name: 1-[(2,3-Dihydro-1,4-benzodioxin-2-yl)methyl]-3-hydroxythieno[3,2-d]pyrimidine-2,4(1H,3H)-dione
Purity: ≥98%
Biological Activity
LNT 1 is a potent flap endonuclease 1 (FEN1) inhibitor (IC50 = 46.4 nM for hFEN1-336Δ). Cytotoxic to SW620 colorectal cancer cells in vitro; induces DNA damage response.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
-
Small molecule inhibitors uncover synthetic genetic interactions of human flap endonuclease 1 (FEN1) with DNA damage response genes.
Ward TA, McHugh PJ, Durant ST.
PLoS ONE. -
Cellularly active N-hydroxyurea FEN1 inhibitors block substrate entry to the active site.
Exell et al.
Nat.Chem.Bio., 2016;12:815
Product Datasheets
Reconstitution Calculator
Molarity Calculator
Citation for LNT 1
The citations listed below are publications that use Tocris products. Selected citations for LNT 1 include:
1 Citation: Showing 1 - 1
-
NAD+ bioavailability mediates PARG inhibition-induced replication arrest, intra S-phase checkpoint and apoptosis in glioma stem cells.
Authors: Mai Et al.
NAR Cancer 2021;3:zcab044
FAQs
No product specific FAQs exist for this product, however you may
View all Small Molecule FAQsReviews for LNT 1
There are currently no reviews for this product. Be the first to review LNT 1 and earn rewards!
Have you used LNT 1?
Submit a review and receive an Amazon gift card.
$25/€18/£15/$25CAN/¥75 Yuan/¥2500 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image
