LUF 5834
Chemical Name: 2-Amino-4-(4-hydroxyphenyl)-6-[(1H-imidazol-2-ylmethyl)thio]-3,5-pyridinecarbonitrile
Purity: ≥98%
Biological Activity
LUF 5834 is a potent A2A and A2B adenosine receptor partial agonist (Ki = 2.6 nM and EC50 = 12 nM respectively). Also exhibits selectivity for A1 over A3 (Ki values are 2.6 and 538 nM respectively).Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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New, non-adenosine, high potency agonists for the human adenosine A2B receptor with an improved selectivity profile compared to the reference agonist N-ethylcarboxamidoadenosine
Beukers et al.
J.Med.Chem, 2004;47:3707 -
A novel nonribose agonist, LUF5834, engages residues that are distinct from those of adenosine-like ligands to activate the adenosine A2a receptor
Lane et al.
Mol.Pharmacol., 2012;81:475
Product Datasheets
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Citations for LUF 5834
The citations listed below are publications that use Tocris products. Selected citations for LUF 5834 include:
2 Citations: Showing 1 - 2
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A2A Adenosine Receptor Partial Agonism Related to Structural Rearrangements in an Activation Microswitch.
Authors: Kurt Et al.
Structure 2021;29:170-176.e3
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Experimental and computational analysis of biased agonism on full-length and a C-terminally truncated adenosine A2A receptor.
Authors: Gemma Et al.
Comput Struct Biotechnol J 2020;18:2723-2732
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