LY 2955303
Chemical Name: 4-[5-[3,5-Bis(1,1-dimethylethyl)phenyl]-1-[4-[(4-methyl-1-piperazinyl)carbonyl]phenyl]-1H-pyrazol-3-yl]benzoic acid
Purity: ≥98%
Biological Activity
LY 2955303 is a high affinity and selective RARγ antagonist (Ki values are 1.1 nM, >1.7 μM and >2.9 μM for RARγ, RARα and RARβ respectively). Displays analgesic efficacy in a mouse model of osteoarthritis-like joint pain.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
-
Identification of potent and selective retinoic acid receptor gamma (RARγ) antagonists for the treatment of osteoarthritis pain using structure based drug design.
Hughes et al.
Bioorg.Med.Chem.Letts., 2016;26:3274
Product Datasheets
Reconstitution Calculator
Molarity Calculator
Citation for LY 2955303
The citations listed below are publications that use Tocris products. Selected citations for LY 2955303 include:
1 Citation: Showing 1 - 1
-
Blockage of retinoic acid signaling via RARγ suppressed the proliferation of pancreatic cancer cells by arresting the cell cycle progression of the G1-S phase.
Authors: Takashi Et al.
Cancer Cell Int 2023;23:94
FAQs
No product specific FAQs exist for this product, however you may
View all Small Molecule FAQsReviews for LY 2955303
There are currently no reviews for this product. Be the first to review LY 2955303 and earn rewards!
Have you used LY 2955303?
Submit a review and receive an Amazon gift card.
$25/€18/£15/$25CAN/¥75 Yuan/¥2500 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image
