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LY 344864 hydrochloride

Catalog #: 2451
3 Citations Datasheet / COA / SDS
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2451/10
2451/50
LY 344864 hydrochloride | CAS No. 1217756-94-9 | 5-HT1F Receptor Agonists
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Description: Potent and selective 5-HT1F agonist

Chemical Name: N-[(3R)-3-(Dimethylamino)-2,3,4,9-tetrahydro-1H-carbazol-6-yl]-4-fluorobenzamide hydrochloride

Purity: ≥99%

Product Details
Citations (3)
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Biological Activity Technical Data Additional Information Background Product Datasheets Calculators

Biological Activity

LY 344864 hydrochloride is a potent, selective 5-HT1F receptor agonist (EC50 = 3 nM). Displays > 80-fold selectivity over other 5-HT receptors (Ki values are 0.006, 0.53, 0.55, 0.56, 1.42, 1.70, 3.50, 3.94 and 4.85 μM for 5-HT1F, 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, 5-HT2B, 5-HT2C, 5-HT2A and 5-HT7 receptors respectively). Inhibits neurogenic dural inflammation in vivo following i.v. and oral administration.

Technical Data

M.Wt:
387.88
Formula:
C21H22N3OF.HCl
Solubility:
Soluble to 50 mM in water and to 100 mM in DMSO
Purity:
≥99%
Storage:
Store at +4°C
CAS No:
1217756-94-9

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Additional Information

Licensing Caveats:
Sold under license from Eli Lilly and Company

Background References

  1. 5-HT1F receptor agonists in acute migraine treatment: a hypothesis.
    Ramadan et al.
    Cephalalgia, 2003;23:776
  2. Evidence for serotonin (5-HT)1B, 5-HT1D and 5-HT1F receptor inhibitory effects on trigeminal neurons with craniovascular input.
    Goadsby and Classey
    Neuroscience, 2003;122:491
  3. Characterization of LY344864 as a pharmacological tool to study 5-HT1F receptors: binding affinities, brain penetration and activity in the neurogenic dural inflammation model of migraine.
    Lee et al.
    Life Science, 1997;61:2117

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Citations for LY 344864 hydrochloride

The citations listed below are publications that use Tocris products. Selected citations for LY 344864 hydrochloride include:

3 Citations: Showing 1 - 3

  1. 5-HT1F receptor-mediated mitochondrial biogenesis for the treatment of Parkinson's disease.
    Authors: Scholpa Et al.
    Br J Pharmacol  2018;175:348
  2. Agonism of the 5-hydroxytryptamine 1F receptor promotes mitochondrial biogenesis and recovery from acute kidney injury.
    Authors: Garrett Et al.
    J Pharmacol Exp Ther  2014;350:257
  3. Polysynaptic excitatory postsynaptic potentials that trigger spasms after spinal cord injury in rats are inhibited by 5-HT1B and 5-HT1F receptors.
    Authors: Murray Et al.
    J Neurophysiol  2011;106:925

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