m-Chlorophenylbiguanide hydrochloride

Catalog #: 0440
4 Citations Datasheet / COA / SDS

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0440/100

m-Chlorophenylbiguanide hydrochloride | CAS No. 2113-05-5 | 5-HT3 Receptor Agonists

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Description: Potent and selective 5-HT3 agonist

Chemical Name: 1-(3-Chlorophenyl)biguanide hydrochloride

Purity: ≥98%

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Product Details

Citations (4)

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Biological Activity

m-Chlorophenylbiguanide hydrochloride is a prototypical potent and selective 5-HT₃ receptor agonist.

Technical Data

M.Wt:

248.11

Formula:

C₈H₁₀ClN₅.HCl

Solubility:

Soluble to 100 mM in water

Purity:

≥98%

Storage:

Desiccate at RT

CAS No:

2113-05-5

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

High-throughput genotoxicity assay identifies antioxidants as inducers of DNA damage response and cell death.
Fox JT, Sakamuru S, Huang R
Proc. Natl. Acad. Sci. U.S.A., 2012;109(14):5423-8.
5HT₃ receptors in NG108-15 neuroblastoma X glioma cells: effect of the novel agonist 1-(m-chlorophenyl)biguanide.
Boess et al.
Neuropharmacology, 1992;31:561
1-(m-Chlorophenyl)biguanide, a potent high affinity 5-HT₃ receptor agonist.
Kilpatrick et al.
Eur.J.Pharmacol., 1990;182:193
The agonist properties of m-chlorophenylbiguanide and 2-methyl-5-hydroxytryptamine on 5-HT₃ receptors in N1E-115 neuroblastoma cells.
Sepulveda et al.
Br.J.Pharmacol., 1991;104:536
Different efficacy of specific agonists at 5-HT₃ receptor splice variants: the role of the extra six amino acid segment.
Niemeyer and Lummis
Br.J.Pharmacol., 1998;123:661

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Citations for m-Chlorophenylbiguanide hydrochloride

The citations listed below are publications that use Tocris products. Selected citations for m-Chlorophenylbiguanide hydrochloride include:

4 Citations: Showing 1 - 4

Vort. disinhibits pyramidal cell function and enhances synaptic plasticity in the rat hippocampus.
Authors: Dale Et al.
J Psychopharmacol 2014;28:891
First and second generation antipsychotics influence hippocampal gamma oscillations by interactions with 5-HT3 and D3 receptors.
Authors: Schulz Et al.
Br J Pharmacol 2012;167:1480
Autocrine and paracrine roles for ATP and serotonin in mouse taste buds.
Authors: Huang Et al.
PLoS One 2009;29:13909
Serotonin modifies cytoskeleton and brush-border membrane architecture in human intestinal epithelial cells.
Authors: Gill Et al.
Am J Physiol Gastrointest Liver Physiol 2008;295:G700

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