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Mandi

Catalog #: 7681 Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
7681/10
Mandi | CAS No. 374726-62-2 | Protein Dimerizers
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Description: Highly efficient chemical inducer of proximity (CIP)

Chemical Name: 4-Chloro-N-[2-[3-methoxy-4-(2-propyn-1-yloxy)phenyl]ethyl]-α-(2-propyn-1-yloxy)benzeneacetamide

Purity: ≥98%

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Biological Activity

Mandi is a chemical inducer of proximity (CIP) in vivo and in vitro (EC50 = 0.43 μM in a luciferase gene expression assay). Mandi induces complex formation between PYR1Mandi, a mutant of Abscisic Acid (Cat. No. 6554) receptor PYR1, and Abscisic Acid insensitive (ABI). Mandi may be used to induce protein colocalization and interaction. It is non-toxic, orthogonal to mammalian processes and other CIPs, and highly cell permeable.

Technical Data

M.Wt:
411.88
Formula:
C23H22ClNO4
Solubility:
Soluble to 100 mM in DMSO
Purity:
≥98%
Storage:
Store at -20°C
CAS No:
374726-62-2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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