MaxiPost
Chemical Name: (3S)-3-(5-Chloro-2-methoxyphenyl)-3-fluoro-1,3-dihydro-6-(trifluoromethyl)-2H-Indol-2-one
Purity: ≥98%
Biological Activity
MaxiPost is a potassium channel modulator. Acts as a positive modulator at neuronal Kv7 channels and calcium-activated K+ channels (BKCa) in HEK293 cells. Displays negative modulatory activity at Kv7.1 channels (Ki = 3.7 μM) and GABAA receptors. Displays anxiolytic activity in vivo.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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Anxiolytic effects of Maxipost (BMS-204352) and retigabine via activation of neuronal Kv7 channels.
Korsgaard et al.
J.Pharmacol.Exp.Ther., 2005;314:282 -
One man's side effect is another man's therapeutic opportunity: targeting Kv7 channels in smooth muscle disorders.
Jepps et al.
Br.J.Pharmacol., 2012;168:19 -
Catalytic enantioselective fluorination of oxindoles.
Hamashima et al.
J.Am.Chem.Soc., 2005;127:10164
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