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MDL 73005EF hydrochloride

Catalog #: 0411 Datasheet / COA / SDS

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0411 has been discontinued.
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MDL 73005EF hydrochloride | CAS No. 102908-60-1 | 5-HT1 Receptor Agonists
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Description: Potent and selective 5-HT1A partial agonist

Chemical Name: 8-[2-(1,4-Benzodioxan-2-ylmethylamino)ethyl]-8-azaspiro[4.5]decane-7,9-dione hydrochloride

Purity: ≥98%

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Biological Activity

MDL 73005EF hydrochloride is a potent and selective 5-HT1A receptor antagonist. Has partial agonist properties.

Technical Data

M.Wt:
394.9
Formula:
C20H26N2O4.HCl
Solubility:
Soluble to 25 mM in water
Purity:
≥98%
Storage:
Store at RT
CAS No:
102908-60-1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. High-throughput genotoxicity assay identifies antioxidants as inducers of DNA damage response and cell death.
    Fox JT, Sakamuru S, Huang R
    Proc. Natl. Acad. Sci. U.S.A., 2012;109(14):5423-8.
  2. Effects of MDL 73005EF on central pre-and-postsynaptic 5HT1A receptor function in the rat in vivo.
    Gartside et al.
    Eur.J.Pharmacol., 1990;191:391
  3. Cardiovascular effects of the 5-HT1A receptor ligand, MDL 73005EF, in conscious hypertensive rats.
    Buisson Defferier and Van den Buuse
    Eur.J.Pharmacol., 1992;223:133
  4. Electrophysiology of the 5-HT1A ligand MDL 73005EF in the rat hippocampal slice.
    Van der Hooff and Galvan
    Eur.J.Pharmacol., 1991;196:291

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