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Me VH 032, amine

Catalog #: 7634 Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
7634/100
Me VH 032, amine | CAS No. 2504950-56-3 | Degrader Building Blocks
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Description: Amine functionalized VHL ligand for PROTAC® research

Chemical Name: (4R)-3-Methyl-L-valyl-4-hydroxy-N-[(1S)-1-[4-(4-methyl-5-thiazolyl)phenyl]ethyl]-L-prolinamide dihydrochloride

Purity: ≥95%

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Biological Activity

Me VH 032, amine is a derivative of the von Hippel-Lindau (VHL) ligand, VH 032 for use as a precursor to a PROTAC® that hijacks VHL as the E3 ubiquitin ligase component. Me VH 032, amine is supplied with a primary amine functional handle, for ready conjugation to a linker/target protein ligand. Introduction of the methyl group at the benzylic position of VH 032 is associated with improved binding affinity.

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PROTAC® is a registered trademark of Arvinas Operations, Inc., and is used under license.

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Usage Guidelines

This product is provided for use in onward chemistry. Suitable solvents can be used.

Technical Data

M.Wt:
517.51
Formula:
C23H32N4O3S.2HCl
Purity:
≥95%
Storage:
Desiccate at RT
CAS No:
2504950-56-3

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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