Melatonin
Chemical Name: N-Acetyl-5-methoxytryptamine
Purity: ≥99%
Biological Activity
Melatonin is an endogenous hormone that acts as an agonist at melatonin receptors MT1 and MT2. Exhibits a prominent role in the control of circadian rhythm, displays immunomodulatory activity and acts as a powerful antioxidant in vivo.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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Thirty four years since the discovery of gastrointestinal melatonin.
Bubenik
J.Physiol.Pharmacol., 2008;59:33 -
Melatonin as a major skin protectant: from free radical scavenging to DNA damage repair.
Fischer et al.
Exp.Dermatol., 2008;17:713 -
Melatonin and melatonergic drugs on sleep: possible mechanisms of action.
Cardinali et al.
Int.J.Neurosci., 2009;119:821
Product Datasheets
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Citations for Melatonin
The citations listed below are publications that use Tocris products. Selected citations for Melatonin include:
10 Citations: Showing 1 - 10
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PDK4 Inhibition Ameliorates Melatonin Therapy by Modulating Cerebral Metabolism and Remyelination in an EAE Demyelinating Mouse Model of Multiple Sclerosis.
Authors: Serge Et al.
Front Immunol 2022;13:862316
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Melatonin Promotes Heterotopic Ossification Through Regulation of Endothelial-Mesenchymal Transition in Injured Achilles Tendons in Rats.
Authors: Jie Et al.
Front Cell Dev Biol 2021;9:629274
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Three-dimensional growth of breast cancer cells potentiates the anti-tumor effects of unacylated ghrelin and AZP-531.
Authors: Vivek Et al.
Elife 2020;9
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Melatonin and Leishmania amazonensis Infection Altered miR-294, miR-30e, and miR-302d Impacting on Tnf, Mcp-1, and Nos2 Expression.
Authors: Fernandes Et al.
Front Cell Infect Microbiol 2019;9:60
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A Differential Hypofunctionality of Gαi Proteins Occurs in Adolescent Idiopathic Scoliosis and Correlates with the Risk of Disease Progression.
Authors: Akoume Et al.
Sci Rep 2019;9:10074
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Homeostatic Plasticity Mediated by Rod-Cone Gap Junction Coupling in Retinal Degenerative Dystrophic RCS Rats.
Authors: Hou Et al.
Front Cell Neurosci 2017;11:98
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The brominated flame retardant BDE-47 causes oxidative stress and apoptotic cell death in vitro and in vivo in mice.
Authors: Costa Et al.
Neurotoxicology 2015;48:68
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Antinociceptive effects of novel melatonin receptor agonists in mouse models of abdominal pain.
Authors: Chen Et al.
Toxicol Sci 2014;20:1298
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Comparative cytotoxicity and intracellular accumulation of five polybrominated diphenyl ether congeners in mouse cerebellar granule neurons.
Authors: Huang Et al.
Nature 2010;114:124
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Neurotoxicity of a polybrominated diphenyl ether mixture (DE-71) in mouse neurons and astrocytes is modulated by intracellular glutathione levels.
Authors: Giordano Et al.
Toxicol Appl Pharmacol 2008;232:161
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