Methysergide maleate
Chemical Name: [8β(S)]-9,10-Didehydro-N-[1-(hydroxymethyl)propyl]-1,6-dimethylergoline-8-carboxamide maleate
Purity: ≥99%
Biological Activity
Methysergide maleate is a mixed 5-HT1/5-HT2 receptor antagonist.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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Activation of raphe nuclei triggers rapid and distinct effects on parallel olfactory bulb output channels.
Kapoor V, Provost A, Agarwal P, Murthy V
Nat Neurosci, 2016;19(2):271-82. -
High-throughput genotoxicity assay identifies antioxidants as inducers of DNA damage response and cell death.
Fox JT, Sakamuru S, Huang R
Proc. Natl. Acad. Sci. U.S.A., 2012;109(14):5423-8. -
VII. International Union of Pharmacology classification of receptors for 5-hydroxytryptamine (serotonin).
Hoyer et al.
Pharmacol.Rev., 1994;46:157
Product Datasheets
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Citations for Methysergide maleate
The citations listed below are publications that use Tocris products. Selected citations for Methysergide maleate include:
7 Citations: Showing 1 - 7
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Reduced levels of serotonin 2A receptors underlie resistance of Egr3-deficient mice to locomotor suppression by cloz.
Authors: Williams Et al.
Neuropsychopharmacology 2012;37:2285
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Maternal influenza viral infection causes schizophrenia-like alterations of 5-HT2A and mGlu2 receptors in the adult offspring.
Authors: Moreno Et al.
Hypertension 2011;31:1863
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Polysynaptic excitatory postsynaptic potentials that trigger spasms after spinal cord injury in rats are inhibited by 5-HT1B and 5-HT1F receptors.
Authors: Murray Et al.
J Neurophysiol 2011;106:925
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Recovery of motoneuron and locomotor function after spinal cord injury depends on constitutive activity in 5-HT2C receptors.
Authors: Murray Et al.
Nat Med 2010;16:694
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Autocrine and paracrine roles for ATP and serotonin in mouse taste buds.
Authors: Huang Et al.
Neuron 2009;29:13909
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Serotonin modulates olfactory processing in the antennal lobe of Drosophila.
Authors: Dacks Et al.
J Neurosci 2009;23:366
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Hallucinogens recruit specific cortical 5-HT(2A) receptor-mediated signaling pathways to affect behavior.
Authors: González-Maeso Et al.
J Neurosci 2007;53:439
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