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Mithramycin A

Catalog #: 1489
6 Citations Datasheet / COA / SDS
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1489/1
Mithramycin A | CAS No. 18378-89-7 | RNA/DNA Polymerase Inhibitors
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Description: Inhibitor of DNA and RNA polymerase

Chemical Name: (1S)-5-Deoxy-1-C-[(2S,3S)-7-[[2,6-dideoxy-3-O-(2,6-dideoxy-β-D-arabino-hexopyranosyl)-β-D-arabino-hexopyranosyl]oxy]-3-[(O-2,6-dideoxy-3-C-methyl-β-D-ribo-hexopyranosyl-(1.fwdarw.3)-O-2,6-dideoxy-β-D-lyxo-hexopyranosyl-(1.fwdarw.3)-2,6-dideoxy-β-D-arabino-hexopyranosyl)oxy]-1,2,3,4-tetrahydro-5,10-dihydroxy-6-methyl-4-oxo-2-anthracenyl]-1-O-methyl-D-threo-2-pentulose

Purity: ≥95%

Product Details
Citations (6)
Reviews
Biological Activity Technical Data Background Product Datasheets Calculators

Biological Activity

Mithramycin A is an anticancer antibiotic that selectively binds to G-C-rich DNA in the presence of Mg2+ or Zn2+, inhibiting RNA and DNA polymerase action. Inhibits c-myc expression and induces myeloid differentiation of HL-60 promyelocytic leukemia cells.

Technical Data

M.Wt:
1085.16
Formula:
C52H76O24
Solubility:
Soluble to 50 mM in DMSO
Purity:
≥95%
Storage:
Store at -20°C
CAS No:
18378-89-7

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. miR-17-3p Contributes to Exercise-Induced Cardiac Growth and Protects against Myocardial Ischemia-Reperfusion Injury
    J Shi, Y Bei, X Kong, X Liu, Z Lei, T Xu, H Wang, Q Xuan, P Chen, J Xu, L Che, H Liu, J Zhong, JP Sluijter, X Li, A Rosenzweig, J Xiao
    Theranostics, 2017;7(3):664-676.
  2. TGF-beta-activated kinase 1 (TAK1) signaling regulates TGF-beta-induced WNT-5A expression in airway smooth muscle cells via Sp1 and beta-catenin.
    Kumawat K, Menzen M, Slegtenhorst R, Halayko A, Schmidt M, Gosens R
    PLoS ONE, 2014;9(4):e94801.
  3. Mithramycin cannot bind to left-handed poly(dG-m5dC) in the presence of Mg2+ ion.
    Demicheli and Garnier-Suillerot
    Biochem.Biophys.Res.Commun., 1991;177:511
  4. Mithramycin selectively inhibits transcription of G-C containing DNA.
    Miller et al.
    Am.J.Med.Sci., 1987;294:388
  5. Mithramycin selectively inhibits the transcriptional activity of a transfected human c-myc gene.
    Ray et al.
    Am.J.Med.Sci., 1990;300:203

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⚠ WARNING: This product can expose you to chemicals including Plicamycin, which is known to the State of California to cause reproductive toxicity with developmental effects. For more information, go to www.P65Warnings.ca.gov

Citations for Mithramycin A

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