MK 386
Chemical Name: (4aR,4bS,6aR,7R,9aS,9bS,10S,11aR)-7-[(1R)-1,5-Dimethylhexyl]hexadecahydro-1,4a,6a,10-tetramethyl-2H-indeno[5,4-f]quinolin-2-one
Purity: ≥98%
Biological Activity
MK 386 is a potent and selective human type 1 5α-reductase inhibitor (5αR1, IC50 = 0.9 nM). Exhibits 100-fold selectivity for 5αR1 over 5αR2 (IC50 = 154 nM). Supresses human serum and sebum dihydrotestosterone (DHT) levels in a dose-dependent manner without affecting semen DHT concentrations. Orally active.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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MK-386, an inhibitor of 5α-reductase type 1, reduces dihydrotestosterone concentrations in serum and sebum without affecting dihydrotestosterone concentrations in semen.
Schwartz et al.
J.Clin.Endocrinol.Metab., 1997;82:1373 -
4,7 beta-Dimethyl-4-azacholestan-3-one (MK-386) and related 4-azasteroids as selective inhibitors of human type 1 5 alpha-reductase.
Bakshi et al.
J.Med.Chem., 1994;37:3871
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