ML 204
Chemical Name: 4-Methyl-2-(1-piperidinyl)quinoline
Purity: ≥99%
Biological Activity
ML 204 is a blocker of TRPC4 channels (IC50 values are 0.96 and 2.6 μM in fluorescent and electrophysiological assays, respectively). Exhibits 19-fold selectivity against TRPC6 and 9-fold selectivity against TRPC5; displays no significant activity at TRPV1, TRPV3, TRPA1 and TRPM8 channels at concentrations up to 22 μM.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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Novel chemical inhibitor of TRPC4 channels.
Miller et al.
Probe Reports from the Molecular Libraries Program, 2011; -
Identification of ML204, a novel potent antagonist that selectively modulates native TRPC4/5 ion channels.
Miller et al.
J.Biol.Chem., 2011;286:33436
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Citation for ML 204
The citations listed below are publications that use Tocris products. Selected citations for ML 204 include:
1 Citation: Showing 1 - 1
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Gut bacteria-derived 5-hydroxyindole is a potent stimulant of intestinal motility via its action on L-type calcium channels.
Authors: Gertjan Et al.
PLoS Biol 2021;19:e3001070
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