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ML 218 hydrochloride

Catalog #: 4507
7 Citations Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
4507/10
4507/50
ML 218 hydrochloride | CAS No. 2319922-08-0 | Cav3.x Channel Blockers
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Description: CaV3.x blocker

Chemical Name: 3,5-Dichloro-N-[[(1α,5α,6-exo,6α)-3-(3,3-dimethylbutyl)-3-azabicyclo[3.1.0]hex-6-yl]methyl]-benzamide hydrochloride

Purity: ≥99%

Product Details
Citations (7)
Reviews
Biological Activity Technical Data Background Product Datasheets Calculators

Biological Activity

ML 218 hydrochloride is a selective inhibitor of T-type calcium channels (IC50 values are 270 and 310 nM for Cav3.3 and Cav3.2 respectively in a patch EP assay). Decreases burst activity in STN neurons; reduces cataleptic behaviour in an in vivo rat model of Parkinson's disease. Displays no significant inhibition of L- or N-type calcium channels, Kir6 (KATP) or KV11.1 (hERG) potassium channels. ML 218 hydrochloride inhibits oral cancer cell proliferation. Orally active.

Technical Data

M.Wt:
405.79
Formula:
C19H26Cl2N2O.HCl
Solubility:
Soluble to 100 mM in DMSO and to 100 mM in ethanol
Purity:
≥99%
Storage:
Store at +4°C
CAS No:
2319922-08-0

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Product Datasheets

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Citations for ML 218 hydrochloride

The citations listed below are publications that use Tocris products. Selected citations for ML 218 hydrochloride include:

7 Citations: Showing 1 - 7

  1. ML218 HCl is more efficient than capsaicin in inhibiting bacterial antigen-induced Cal 27 oral cancer cell proliferation.
    Authors: Chakraborty Et al.
    Int.J.Mol.Sci.  2021;22:12559
  2. Role of L-Type Voltage-Gated Calcium Channels in Epileptiform Activity of Neurons.
    Authors: Artem M Et al.
    Int J Mol Sci  2021;22
  3. STIM1 deficiency is linked to Alzheimer's disease and triggers cell death in SH-SY5Y cells by upregulation of L-type voltage-operated Ca2+ entry.
    Authors: Pascual-Caro Et al.
    J Mol Med (Berl)  2018;96:1061
  4. MECHANISMS UNDERLYING ACTION OF XINMAILONG INJECTION, A TRADITIONAL CHINESE MEDICINE IN CARDIAC FUNCTION IMPROVEMENT.
    Authors: Li Et al.
    Afr J Tradit Complement Altern Med  2017;14:241
  5. Lack of antiparkinsonian effects of systemic injections of the specific T-type calcium channel blocker ML218 in MPTP-treated monkeys.
    Authors: Galvan Et al.
    ACS Chem.Neurosci.  2016;7:1543
  6. T-type calcium channels contribute to calcium disturbances in brain during hyponatremia.
    Authors: Nisha Et al.
    Exp Neurol  2015;273:105-13

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