ML 335

Catalog #: 6887
2 Citations Datasheet / COA / SDS

Catalog #	Availability	Size / Price	Qty
6887/10
6887/50

ML 335 | CAS No. 825658-06-8 | Two-P Potassium Channels Activators

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Description: Selective K2P2.1 (TREK-1) and K2P10.1 (TREK-2) activator

Chemical Name: N-[(2,4-Dichlorophenyl)methyl]-4-[(methylsulfonyl)amino]benzamide

Purity: ≥98%

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Product Details

Citations (2)

Reviews

Biological Activity Technical Data Background Product Datasheets Calculators

Biological Activity

ML 335 is a selective K_2P2.1 (TREK-1; KCNK2) and K_2P10.1 (TREK-2; KCNK10) activator (EC₅₀ values of 14.3 μM and 5.2 μM, respectively); directly stimulates the C-type gate via the K_2P modulator pocket. Does not activate K_2P4.1 (TRAAK).

Technical Data

M.Wt:

373.25

Formula:

C₁₅H₁₄Cl₂N₂O₃S

Solubility:

Soluble to 100 mM in DMSO and to 20 mM in ethanol

Purity:

≥98%

Storage:

Store at +4°C

CAS No:

825658-06-8

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

A pharmacological master key mechanism that unlocks the selectivity filter gate in K⁺ channels.
Schewe et al.
Science, 2019;363:875
Protein and chemical determinants of BL-1249 action and selectivity for K_2P channels.
Pope et al.
ACS Chem.Neurosci., 2018;9:3153
Two-pore domain potassium channels: emerging targets for novel analgesic drugs: IUPHAR Review 26.
Gada et al.
Br.J.Pharmacol., 2019;176:256
K_2P2.1 (TREK-1)-activator complexes reveal a cryptic selectivity filter binding site.
Lolicato et al.
Nature, 2017;547:364

Product Datasheets

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M. Wt* g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Citations for ML 335

The citations listed below are publications that use Tocris products. Selected citations for ML 335 include:

2 Citations: Showing 1 - 2

Albumin Reduces Oxidative Stress and Neuronal Apoptosis via the ERK/Nrf2/HO-1 Pathway after Intracerebral Hemorrhage in Rats.
Authors: Peng Et al.
Oxid Med Cell Longev 2021;2021:8891373
Recombinant CCL17 Enhances Hematoma Resolution and Activation of CCR4/ERK/Nrf2/CD163 Signaling Pathway After Intracerebral Hemorrhage in Mice.
Authors: Lei Et al.
Neurotherapeutics 2020;17:1940-1953

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