ML 365
Chemical Name: 2-Methoxy-N-[3-[(3-methylbenzoyl)amino]phenyl]benzamide
Purity: ≥99%
Biological Activity
ML 365 is a potent and selective TASK-1 (K2P3.1/KCNK3) channel blocker (IC50 values are 4 and 390 nM at TASK-1 and TASK-3, respectively). Displays little or no inhibition at Kir2.1, voltage-gated potassium channels, KCNQ2 and KV11.1 (hERG).Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
-
Potent and selective inhibitors of the TASK-1 potassium channel through chemical optimization of a bis-amide scaffold.
Flaherty et al.
Bioorg.Med.Chem.Lett., 2014;24:3968 -
ML365: Development of bis-amides as selective inhibitors of the KCNK3/TASK1 two pore potassium channel.
Zou et al.
Probe Reports from the NIH Molecular Libraries Program, 2013;
Product Datasheets
Reconstitution Calculator
Molarity Calculator
Citations for ML 365
The citations listed below are publications that use Tocris products. Selected citations for ML 365 include:
4 Citations: Showing 1 - 4
-
Modulation of TASK-1/3 channels at the hypoglossal motoneuron pool and effects on tongue motor output and responses to excitatory inputs in vivo: implications for strategies for obstructive sleep apnea pharmacotherapy.
Authors: Richard L Et al.
Sleep 2021;44
-
How Gastrin-Releasing Peptide Opens the Spinal Gate for Itch.
Authors: Pagani Et al.
Neuron 2019;
-
Neurokinin-3 receptor activation selectively prolongs atrial refractoriness by inhibition of a background K+ channel.
Authors: Veldkamp Et al.
Nat. Commun. 2018;9:4357
-
TALK-1 channels control β cell endoplasmic reticulum Ca2+ homeostasis.
Authors: Vierra Et al.
Sci Signal 2017;10
FAQs
No product specific FAQs exist for this product, however you may
View all Small Molecule FAQsReviews for ML 365
There are currently no reviews for this product. Be the first to review ML 365 and earn rewards!
Have you used ML 365?
Submit a review and receive an Amazon gift card.
$25/€18/£15/$25CAN/¥75 Yuan/¥2500 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image
