ML 418

Catalog #: 6889 Datasheet / COA / SDS

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ML 418 | CAS No. 1928763-08-9 | Inward Rectifier Potassium Channel Blockers

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Description: Kir 7.1 inhibitor; also inhibits Kir 6.2

Chemical Name: Isopropyl (1-((5-chloro-8-hydroxyquinolin-7-yl)methyl)piperidin-4-yl)carbamate

Purity: ≥98%

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Biological Activity Technical Data Background Product Datasheets Calculators

Biological Activity

ML 418 is a K_ir7.1 inhibitor (IC₅₀ = 0.31 μM). Also inhibits K_ir6.2 with similar potency. Displays >17-fold selectivity for K_ir7.1 over K_ir1.1, K_ir2.1, K_ir2.2, K_ir2.3, K_ir3.1/3.2 and K_ir4.1. Active in vivo.

Technical Data

M.Wt:

377.87

Formula:

C₁₉H₂₄CIN₃O₃

Solubility:

Soluble to 20 mM in DMSO

Purity:

≥98%

Storage:

Store at -20°C

CAS No:

1928763-08-9

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

ML418: the first selective, sub-micromolar pore blocker of K_ir7.1 potassium channels.
Swale et al.
ACS Chem.Neurosci., 2016;7:1013
Pore polarity and charge determine differential block of K_ir1.1 and K_ir7.1 potassium channels by small-molecule inhibitor VU590.
Kharade
Mol.Pharmacol., 2017;92:338

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