ML SA1
Chemical Name: 2-[2-(3,4-Dihydro-2,2,4-trimethyl-1(2H)-quinolinyl)-2-oxoethyl]-1H-isoindole-1,3(2H)-dione
Purity: ≥98%
Biological Activity
ML SA1 is an activator of TRPML channels (TRPML1, 2 and 3); does not activate TRPM2, TRPV2, TRPV3, TRPC6 or TRPA1 channels. Induces TRPML-mediated Ca2+ release from lysosomes; activity corrects trafficking defects and reduces cholesterol accumulation in Niemann-Pick type C macrophages. Activation of TRPML1 by ML SA1 causes membrane accumulation of aquaporin-3 and -5, and significant depolymerization of the actin cytoskeleton, in human lymphatic endothelial cells (HLECs).Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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Lipid storage disorders block lysosomal trafficking by inhibiting TRP channel and calcium release.
Shen et al.
Nat.Commun., 2012;3:731 -
Cross-talk between TRPML1 channel, lipids and lysosomal storage diseases.
Weiss et al.
Commun.Integr.Biol., 2012;5:111
Product Datasheets
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Citations for ML SA1
The citations listed below are publications that use Tocris products. Selected citations for ML SA1 include:
9 Citations: Showing 1 - 9
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TRPML1 acts as a predisposing factor in lymphedema development by regulating the subcellular localization of aquaporin-3, -5.
Authors: Yang Et al.
PLoS One 2024;19:e0310653
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Phospholipase D3 degrades mitochondrial DNA to regulate nucleotide signaling and APP metabolism.
Authors: Wim Et al.
Nat Commun 2023;14:2847
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LAMTOR1 inhibition of TRPML1-dependent lysosomal calcium release regulates dendritic lysosome trafficking and hippocampal neuronal function.
Authors: Yan Et al.
EMBO J 2022;41:e108119
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A protocol to measure lysosomal Zn2+ release through a genetically encoded Zn2+ indicator.
Authors: Haoxing Et al.
STAR Protoc 2022;3:101453
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Lysosomes and the pathogenesis of merosin-deficient congenital muscular dystrophy.
Authors: Steven A Et al.
Hum Mol Genet 2022;31:733-747
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Microtubules restrict F-actin polymerization to the immune synapse via GEF-H1 to maintain polarity in lymphocytes.
Authors: Jacques Et al.
Elife 2022;11
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Berbamine inhibits Japanese encephalitis virus (JEV) infection by compromising TPRMLs-mediated endolysosomal trafficking of low-density lipoprotein receptor (LDLR).
Authors: Wei Et al.
Emerg Microbes Infect 2021;10:1257-1271
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Trpml controls actomyosin contractility and couples migration to phagocytosis in fly macrophages.
Authors: Ana-Maria Et al.
J Cell Biol 2020;219
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Structural basis for PtdInsP2-mediated human TRPML1 regulation.
Authors: Fine Et al.
Nat.Commun. 2018;9:4192
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