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MO-I-500

Catalog #: 6871 Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
6871/10
6871/50
MO-I-500 | CAS No. 1585219-04-0 | Other Oxidase/Oxygenase Compounds
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Description: FTO inhibitor; anticonvulsant

Chemical Name: N-[5-(4-Chlorophenyl)-3,4-dihydroxy-2-furanyl]ethanesulfonamide

Purity: ≥98%

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Biological Activity

MO-I-500 is a FTO inhibitor (IC50 = 8.7 μM for purified FTO in vitro), which increases N6-methyladenosine (m6A) levels in total cellular mRNA in HeLa cells. MO-I-500 modulates levels of specific miRNAs. In a triple-negative breast cancer cell line metabolically challenged by culture without glutamine (SUM149-MA cells), MO-I-500 inhibits cell proliferation. MO-I-500 also displays anticonvulsant activity in a 6 Hz mouse model of epilepsy at nontoxic doses.

Technical Data

M.Wt:
317.75
Formula:
C12H12ClNO5S
Solubility:
Soluble to 100 mM in DMSO
Purity:
≥98%
Storage:
Store at -20°C
CAS No:
1585219-04-0

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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