MONNA
Chemical Name: 2-[(4-Methoxy-2-naphthalenyl)amino]-5-nitro-benzoic acid
Purity: ≥98%
Biological Activity
MONNA is a potent TMEM16A (Anoctamin-1) blocker (IC50 = 80 nM). Exhibits >100-fold selectivity for TMEM16A over bestrophin-1, CLC2 and CFTR. Induces vasorelaxation of rodent resistance arteries in presence or absence of chloride ions. Carbachol (Cat. No. 2810) induced contraction of bronchial myocytes is reduced by MONNA and intracellular calcium release is increased.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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MONNA, a potent and selective blocker for transmembrane protein with unknown function 16/anoctamin-1.
Oh et al.
Mol.Pharmacol., 2013;84:726 -
New selective inhibitors of calcium-activated chloride channels - T16A(inh) -A01, CaCC(inh) -A01 and MONNA - what do they inhibit?
Boedtkjer et al.
Br.J.Pharmacol., 2015;172:4158
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Citations for MONNA
The citations listed below are publications that use Tocris products. Selected citations for MONNA include:
2 Citations: Showing 1 - 2
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The TMEM16A blockers benzbromarone and MONNA cause intracellular Ca2+-release in mouse bronchial smooth muscle cells
Authors: Dwivedi Et al.
Eur J Pharmacol 2023;
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Evidence for tetrodotoxin-resistant spontaneous myogenic contractions of mouse isolated stomach that are dependent on acetylcholine.
Authors: Armen Et al.
Br J Pharmacol 2022;179:1187-1200
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