Motilin (human, porcine)
Purity: ≥95%
Biological Activity
Motilin (human, porcine) is an endogenous motilin receptor ligand (Ki = 2.3 nM) that regulates gastrointestinal motor function. Stimulates contraction of gut smooth muscle (EC50 = 1 nM) and increases pepsin release.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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Motilin and clinical application.
Itoh
Peptides, 1997;18:593 -
Identification of peptide ligand-binding domains within the human motilin receptor using photoaffinity labeling.
Coulie et al.
J.Biol.Chem., 2001;276:35518 -
Signaling pathways mediating gastrointestinal smooth muscle contraction and MLC20 phosphorylation by motilin receptors.
Huang et al.
Am.J.Physiol.Gastrointest.Liver Physiol., 2005;288:G23
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Citation for Motilin (human, porcine)
The citations listed below are publications that use Tocris products. Selected citations for Motilin (human, porcine) include:
1 Citation: Showing 1 - 1
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The antibiotic azithro. is a motilin receptor agonist in human stomach: comparison with erythro.
Authors: Broad and Sanger
Br J Pharmacol 2013;168:1859
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