Mouse CCL2/JE/MCP-1 Biotin Fluorokine Flow Cytometry Kit

Discontinued Product

NFJE0 has been discontinued.
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Citations (5)
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Mouse CCL2/JE/MCP-1 Biotin Fluorokine Flow Cytometry Kit Summary

Specifications

Source
N/A
Shipping Conditions
The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.
Storage
Store the unopened product at 2 - 8 °C. Do not use past expiration date.
Species
Mouse

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Background: CCL2/JE/MCP-1

CCL2/JE/MCP-1, is a chemokine that binds the receptor CCR2 and induces the chemoattraction of mononuclear cells. It induces the activation of monocytes, NK cells, lymphocytes, and basophils. Additionally, CCL2 promotes Th2 polarization in CD4+ T cells, and CCL2-mediated recruitment of monocytes to sites of inflammation contributes to disease severity in atherosclerosis, multiple sclerosis, and allergic asthma. Endogenous proteolytic trimming of CCL2 at the N-terminus, including the N-terminal pyrrolidone carboxylic acid-modified glutamine, downregulates activity but not receptor binding.

Entrez Gene IDs
6347 (Human); 20296 (Mouse); 24770 (Rat); 403981 (Canine)
Alternate Names
C-C motif chemokine ligand 2; CCL2; GDCF-2; HC11; HSMCR30; MCAF; Mcp1; MCP-1; SCYA2; SMC-CF

Citations for Mouse CCL2/JE/MCP-1 Biotin Fluorokine Flow Cytometry Kit

R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.

5 Citations: Showing 1 - 5
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  1. Urokinase-type plasminogen activator plays essential roles in macrophage chemotaxis and skeletal muscle regeneration.
    Authors: Bryer SC, Fantuzzi G, Van Rooijen N, Koh TJ
    J. Immunol., 2008-01-15;180(2):1179-88.  2008-01-15
  2. The binding of CCL2 to the surface of Trypanosoma cruzi induces chemo-attraction and morphogenesis.
    Authors: Yamauchi LM, Aliberti JC, Baruffi MD, Portela RW, Rossi MA, Gazzinelli RT, Mineo JR, Silva JS
    Microbes Infect., 2006-12-08;9(1):111-8.  2006-12-08
  3. Novel chemokine responsiveness and mobilization of neutrophils during sepsis.
    Authors: Speyer CL, Gao H, Rancilio NJ, Neff TA, Huffnagle GB, Sarma JV, Ward PA
    Am. J. Pathol., 2004-12-01;165(6):2187-96.  2004-12-01
  4. Expression of L-CCR in HEK 293 cells reveals functional responses to CCL2, CCL5, CCL7, and CCL8.
    Authors: Biber K, Zuurman MW, Homan H, Boddeke HW
    J. Leukoc. Biol., 2003-08-01;74(2):243-51.  2003-08-01
  5. Possible co-regulation of genes associated with enhanced progression of mammary adenocarcinomas.
    Authors: Neumark E, Cohn MA, Lukanidin E, Witz IP, Ben-Baruch A
    Immunol. Lett., 2002-06-03;82(1):111-21.  2002-06-03

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