Mouse CRHBP Antibody

Catalog #: MAB3087 Datasheet / COA / SDS

Catalog #	Availability	Size / Price	Qty
MAB3087
MAB3087-SP

All CRHBP Antibodies

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Summary Preparation and Storage Reconstitution Calculator Background Product Datasheets Related Research Areas

Mouse CRHBP Antibody Summary

Species Reactivity

Mouse

Specificity

Detects mouse CRHBP in direct ELISAs and Western blots. In direct ELISAs and Western blots, no cross‑reactivity with recombinant human CRHBP is observed.

Source

Monoclonal Rat IgG_2A Clone # 356803

Purification

Protein A or G purified from hybridoma culture supernatant

Immunogen

Mouse myeloma cell line NS0-derived recombinant mouse CRHBP
Tyr25-Leu322
Accession # Q60571

Formulation

Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 µm filtered solution in PBS.

Applications

Recommended Concentration

Sample

Western Blot

1 µg/mL

Recombinant Mouse CRHBP

Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.

Reconstitution Calculator

Preparation and Storage

Reconstitution

Reconstitute at 0.5 mg/mL in sterile PBS.

Shipping

Lyophilized product is shipped at ambient temperature. Liquid small pack size (-SP) is shipped with polar packs. Upon receipt, store immediately at the temperature recommended below.

Stability & Storage

Use a manual defrost freezer and avoid repeated freeze-thaw cycles.

12 months from date of receipt, -20 to -70 °C as supplied.
1 month, 2 to 8 °C under sterile conditions after reconstitution.
6 months, -20 to -70 °C under sterile conditions after reconstitution.

Background: CRHBP

Mouse CRHBP (Corticotrophin-Releasing Hormone Binding Protein) is a 37 kDa monomeric CRH-binding glycoprotein that is secreted by cells of the rodent adrenal medulla, cortical neurons and astrocytes, and prolactin positive cells of the pituitary. The mature molecule is 298 aa in length and contains six intrachain disulfide bonds. It binds CRH and CRH-like peptides, either serving as an antagonist for CRH binding to CRH receptor 1, or as a coreceptor for CRH binding to CRH receptor 2. Mature mouse CRHBP shares 94%, 87%, 85%, and 80% aa sequence identity with rat, human, canine and bovine CRHBP, respectively.

Long Name

Corticotropin Releasing Hormone Binding Protein

Entrez Gene IDs

1393 (Human)

Alternate Names

corticotropin releasing hormone binding protein; corticotropin-releasing factor-binding protein; Corticotropin-releasing hormone-binding protein; CRFBP; CRFBPcorticotropin releasing hormone-binding protein; CRF-BPCRF-binding protein; CRHBP; CRH-BP