Mouse CXCR7/RDC-1 APC-conjugated Antibody

Name: Mouse CXCR7/RDC-1 APC-conjugated Antibody
Brand: R&D Systems
SKU: FAB7167A

Catalog #: FAB7167A Datasheet / COA / SDS

Discontinued Product

FAB7167A has been discontinued.

View all CXCR7/RDC-1 products.

Detection of CXCR7/RDC‑1 in D3 Mouse Cell Line by Flow Cytometry.

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All CXCR7/RDC-1 Antibodies

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Mouse CXCR7/RDC-1 APC-conjugated Antibody Summary

Species Reactivity

Mouse

Specificity

Detects mouse CXCR7/RDC-1 in direct ELISAs.

Source

Monoclonal Rat IgM Clone # 734110

Purification

Protein A or G purified from hybridoma culture supernatant

Immunogen

E. coli-derived recombinant mouse CXCR7/RDC-1 extracellular N-terminus and loops
Met1-Leu47, Ser103-Lys118, Lys184-Glu213, Leu274-Ala296
Accession # P56485

Formulation

Supplied in a saline solution containing BSA and Sodium Azide.

Label

Allophycocyanin (Excitation= 620-650 nm, Emission= 660-670 nm)

Applications

Recommended Concentration

Sample

Flow Cytometry

10 µL/10⁶ cells

See below

Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.

Scientific Data

Flow Cytometry

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Detection of CXCR7/RDC‑1 in D3 Mouse Cell Line by Flow Cytometry. D3 mouse embryonic stem cell line was stained with Rat Anti-Mouse CXCR7/RDC‑1 APC‑conjugated Monoclonal Antibody (Catalog # FAB7167A, filled histogram) or isotype control antibody rat Igm isotype control. View our protocol for Staining Membrane-associated Proteins.

Reconstitution Calculator

Preparation and Storage

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Protect from light. Do not freeze.

12 months from date of receipt, 2 to 8 °C as supplied.

Background: CXCR7/RDC-1

CXCR7 (CXC chemokine receptor 7; also GPRN1, RDC-1 and chemokine orphan receptor 1) is a 60 kDa member of the G-protein coupled receptor 1 family. It is expressed on multiple cell types, including neurons, T cells, NK cells, neutrophils, B cells plus angiogenic endothelial cells. CXCR7 forms both homodimers and heterodimers with CXCR4. It selectively binds I-TAC and SDF-1, and appears to involve beta -arrestin2 during signaling. Notably, a CXCR7:CXCR4 heterodimer shows increased responsiveness to SDF-1, and I-TAC may actually block some SDF-1-mediated migration activity. Mouse CXCR7 is a 7-transmembrane glycoprotein that is 362 amino acids (aa) in length. It contains a 47 aa N-terminal extracellular region plus a 43 aa C-terminal cytoplasmic domain. Over the collective extracellular domains (aa 1-47, 103-118, 184-213 and 274-296), mouse CXCR7 shares 97% and 91% aa identity with rat and human CXCR7, respectively.

Entrez Gene IDs

57007 (Human); 12778 (Mouse); 84348 (Rat)

Alternate Names

ACKR3; chemokine (C-X-C motif) receptor 7; Chemokine orphan receptor 1CMKOR1C-X-C chemokine receptor type 7; CMKOR1; CXCR7; CXC-R7; CXCR-7; G protein-coupled receptor; GPR159; GPR159G-protein coupled receptor 159; RDC-1; RDC1G-protein coupled receptor RDC1 homolog