Mouse Decorin Biotinylated Antibody Summary
Gly17-Lys354
Accession # P28654
Applications
Mouse Decorin Sandwich Immunoassay
Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.
Scientific Data
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Decorin in Mouse Dorsal Root Ganglia. Decorin was detected in perfusion fixed frozen sections of mouse dorsal root ganglia using 15 µg/mL Goat Anti-Mouse Dec-orin Biotinylated Antigen Affinity-purified Polyclonal Antibody (Catalog # BAF1060) overnight at 4 °C. Tissue was stained with the Anti-Goat HRP-DAB Cell & Tissue Staining Kit (brown; Catalog # CTS008) and counter-stained with hematoxylin (blue). View our protocol for Chromogenic IHC Staining of Paraffin-embedded Tissue Sections.
Reconstitution Calculator
Preparation and Storage
- 12 months from date of receipt, -20 to -70 °C as supplied.
- 1 month, 2 to 8 °C under sterile conditions after reconstitution.
- 6 months, -20 to -70 °C under sterile conditions after reconstitution.
Background: Decorin
Decorin is a small secreted chondroitin/dermatan sulfate proteoglycan belonging to the class I small leucine-rich proteoglycan family (SLRP). All SLRP family members are characterized by the N-terminal and C-terminal cysteine-rich regions, which flank the central region containing 10‑12 tandem leucine-rich repeats. In mouse Decorin, the glycosaminoglycan chain is O-linked to Ser34 in the N-terminal disulfide-bridged loop. Decorin binds to fibronectin, TGF-beta, type I and type II collagen. The binding of Decorin to these molecules is mediated via the core protein. Decorin plays a role in maintaining collagen fibrillogenesis. Depending on the cell context, Decorin can either block or augment the bioactivity of TGF-beta Decorin induces growth suppression by activation of a signaling pathway that culminates in the blockade of the cell cycle machinery. Decorin can also induce fibroblast cytoskeletal and signalling changes that results in an increased cell migration (1, 2).
- Iozzo, R.V. (1998) Annu. Rev. Biochem. 67:609.
- Tufvesson, E. and G. Westergren-Thorsson (2003) J. Cell Science 116:4857.
Product Datasheets
Citations for Mouse Decorin Biotinylated Antibody
R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.
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Absence of fibromodulin affects matrix composition, collagen deposition and cell turnover in healthy and fibrotic lung parenchyma.
Authors: Rydell-Tormanen K, Andreasson K, Hesselstrand R, Westergren-Thorsson G
Sci Rep, 2014-09-18;4(0):6383.
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5‐HT 2B receptor antagonists attenuate myofibroblast differentiation and subsequent fibrotic responses in vitro and in vivo
Authors: Anna Löfdahl, Kristina Rydell-Törmänen, Catharina Müller, C. Martina Holst, Lena Thiman, Gunilla Ekström et al.
Physiological Reports
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Glycosaminoglycan Modification of Decorin Depends on MMP14 Activity and Regulates Collagen Assembly
Authors: AC Daquinag, Z Gao, C Fussell, K Sun, MG Kolonin
Cells, 2020-12-09;9(12):.
Species: Mouse
Sample Types: Cell Lysates
Applications: Western Blot
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