Mouse EphA7 Antibody Summary
Ala30-Pro554 (Gly540-Glu544 del)
Accession # Q61772
Applications
Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.
Reconstitution Calculator
Preparation and Storage
- 12 months from date of receipt, -20 to -70 °C as supplied.
- 1 month, 2 to 8 °C under sterile conditions after reconstitution.
- 6 months, -20 to -70 °C under sterile conditions after reconstitution.
Background: EphA7
EphA7, also known as Mdk1, Hek11, Ehk3, Ebk, and Cek11 (1), is a member of the Eph receptor family which binds members of the ephrin ligand family. There are two classes of receptors, designated A and B. Both the A and B class receptors have an extracellular region consisting of a globular domain, a cysteine-rich domain, and two fibronectin type III domains. This is followed by the transmembrane region and the cytoplasmic region. The cytoplasmic region contains a juxtamembrane motif with two tyrosine residues, which are the major autophosphorylation sites, a kinase domain, and a conserved sterile alpha motif (SAM) in the carboxy tail which contains one conserved tyrosine residue. Activation of kinase activity occurs after ligand recognition and binding. EphA7 has been shown to bind ephrin-A2, ephrin-A3, ephrin-A1, ephrin-A4, and ephrin-A5 (2, 3). The extracellular domains of human and mouse EphA7 share greater than 97% amino acid identity. Only membrane-bound or Fc-clustered ligands are capable of activating the receptor in vitro. While soluble monomeric ligands bind the receptor, they do not induce receptor autophosphorylation and activation (2). In vivo, the ligands and receptors display reciprocal expression (3). It has been found that nearly all receptors and ligands are expressed in developing and adult neural tissue (3). The Eph/ephrin families also appear to play a role in angiogenesis (3).
- Eph Nomenclature Committee [letter] (1997) Cell 90:403.
- Flanagan, J.G. and P. Vanderhaegen (1998) Annu. Rev. Neurosci. 21:309.
- Pasquale, E.B. (1997) Curr. Opin. Cell. Biol. 9:608.
Product Datasheets
Citations for Mouse EphA7 Antibody
R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.
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Expression and activation of ephexin is altered after spinal cord injury
Authors: Odrick R. Rosas, Johnny D. Figueroa, Aranza I. Torrado, Mónica Rivera, José M. Santiago, Franchesca Konig-Toro et al.
Developmental Neurobiology
Species: Rat
Sample Types: Whole Tissue
Applications: IHC -
Mutually Repulsive EphA7–EfnA5 Organize Region-to-Region Corticopontine Projection by Inhibiting Collateral Extension
Species: Mouse
Sample Types: Cell Lysates, Tissue Homogenates
Applications: Western Blot -
Polysialylated NCAM and EphrinA/EphA Regulate Synaptic Development of GABAergic Interneurons in Prefrontal Cortex
Species: Mouse
Sample Types: Tissue Homogenates
Applications: Immunoprecipitation -
EphA7 Expression Identifies a Unique Neuronal Compartment in the Rat Striatum
Species: Mouse
Sample Types: Cell Lysates, Recombinant Protein, Whole Tissue
Applications: IHC, Western Blot
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