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Mouse Erythropoietin/EPO Quantikine ELISA Kit

Catalog #: MEP00B
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Mouse Erythropoietin ELISA Standard Curve
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Summary Precision Recovery Linearity Data Examples Product Datasheets Preparation and Storage Background Related Research Areas

Mouse Erythropoietin/EPO Quantikine ELISA Kit Summary

Assay Length
4.5 hours
Sample Type & Volume Required Per Well
Cell Culture Supernates (50 uL), Tissue Homogenates (50 uL), Serum (25 uL), Heparin Plasma (25 uL)
Sensitivity
46.9 pg/mL
Assay Range
47.0 - 3,000 pg/mL (Cell Culture Supernates, Tissue Homogenates, Serum, Heparin Plasma)
Specificity
Natural and recombinant mouse Epo. Recombinant rat Epo has 100% cross-reactivity in this kit. This kit is not validated for use with rat samples, because rat sample dilution is not linear.
Cross-reactivity
< 0.5% cross-reactivity observed with available related molecules.< 50% cross-species reactivity observed with species tested.
Interference
Interference observed with 1 or more available related molecules.

Product Summary

The Quantikine Mouse Epo Immunoassay is a 4.5 hour solid-phase ELISA designed to measure mouse Epo in cell culture supernates, tissue homogenates, serum, and plasma. It contains antibodies raised against recombinant Epo and has been shown to accurately quantitate the recombinant factor. Results obtained using natural mouse Epo showed linear curves that were parallel to the standard curves obtained using the Quantikine kit standards. These results indicate that the Quantikine Mouse Epo kit can be used to determine relative mass values for naturally occurring mouse Epo.

Precision

Intra-Assay Precision (Precision within an assay) Three samples of known concentration were tested on one plate to assess intra-assay precision
Inter-Assay Precision (Precision between assays) Three samples of known concentration were tested in separate assays to assess inter-assay precision

Cell Culture Supernates, Tissue Homogenates, Serum, Heparin Plasma

Intra-Assay Precision Inter-Assay Precision
Sample 1 2 3 1 2 3
n 20 20 20 20 20 20
Mean (pg/mL) 196 258 704 180 239 700
Standard Deviation 7.7 7.8 31.2 17.5 15.3 17.5
CV% 3.9 3 4.4 9.7 6.4 2.5

Recovery

The recovery of Epo spiked to three levels throughout the range of the assay in various matrices was evaluated.

Sample Type Average % Recovery Range %
Cell Culture Supernates (n=7) 110 102-117
Heparin Plasma (n=8) 103 90-120
Serum (n=9) 93 85-114
Tissue Homogenates (n=3) 94 80-111

Linearity

To assess the linearity of the assay, samples containing or spiked with high concentrations of Epo in each matrix were diluted with Calibrator Diluent and then assayed.
Mouse Erythropoietin ELISA Linearity

Scientific Data

N/A Mouse Erythropoietin ELISA Standard Curve View Larger

Mouse Erythropoietin ELISA Standard Curve

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Preparation and Storage

Shipping
The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.
Storage
Store the unopened product at 2 - 8 °C. Do not use past expiration date.

Background: Erythropoietin/EPO

Erythropoietin (Epo) is a 34-39 kDa secreted glycoprotein that is a member of the type I cytokine superfamily. The mouse Epo gene encodes a 192 amino acid (aa) residue precursor that contains a 26 aa signal peptide and a 166 aa mature protein containing three potential N-linked glycosylation sites (1-4). Mouse Epo lacks the O-linked glycosylation site found in human Epo. Although carbohydrate chains are not required for in vitro receptor binding, they are required for in vivo Epo bioactivity. Depending on the cell source, different Epo isoforms are produced that differ in their glycan compositions and sialic acid contents (5-8). Mature mouse and rat Epo share 94% aa sequence identity. They also share from 80%-82% aa identity with mature human, porcine, rhesus monkey and feline Epo (2, 3). Epo is primarily produced by cells in the kidney (interstitial peritubular renal fibroblasts) and liver (hepatocytes and Ito cells), where its production is up-regulated by hypoxia. Other tissues and cells, including neural tissues (astrocytes and neurons), testis (Sertoli cells), uterus, placenta, and erythroid progenitors, have also been shown to produce Epo (9-14). 

Epo is best known for its role in red blood cell formation. While Epo is not a lineage commitment factor, it inhibits apoptosis and induces burst forming unit-erythroid (BFU-E) differentiation into colony forming unit-erythroid (CFU-E), and the subsequent proliferation and maturation of CFU-E into early normoblasts (10, 15, 16). Apart from its role in erythropoiesis, Epo also acts on various non-hematopoietic cells to function as a viability and proliferation factor. Epo can stimulate myoblast proliferation while suppressing its differentiation, resulting in the expansion of the progenitor cell population (17). Epo is a tissueprotective factor that protects against ischemic and toxic injuries to neuronal, cardiovascular and renal tissues (18, 19). Epo has also been shown to promote angiogenesis in various physiologic and pathologic conditions (20, 21). 
Epo binds and signals via the high-affinity preformed homodimeric Epo receptor (Epo R) that is composed of two Epo R subunits. Each Epo R subunit is a type I transmembrane glycoprotein that belongs to the type I cytokine receptor superfamily (18, 22-24). Its extracellular domain contains the characteristic two fibronectin type III domains and a WSxWS motif near the plasma membrane (24, 25). Binding of Epo to the Epo R homodimer results in conformational change and phosphorylation and activation of the non-receptor protein kinase JAK2, which activates the downstream signaling cascade (26). An alternative Epo heteromeric receptor complex that transduces cell-protective signals and containing the beta common receptor ( beta CR) subunit in addition to the Epo R subunit has been described. beta CR also belongs to the type I cytokine receptor superfamily and is a subunit that is shared by the heteromeric IL-3, IL-5 and GM-CSF receptor complexes. Epo binds with lower affinity to the heteromeric receptor consisting of a Epo R subunit and a beta CR homodimer (18).

Entrez Gene IDs:
2056 (Human); 13856 (Mouse); 24335 (Rat)
Alternate Names:
ECYT5; EP; EPO; epoetin; Erythropoietin; MGC138142; MVCD2
&#9888; WARNING: This product can expose you to chemicals including N,N-Dimethylforamide, which is known to the State of California to cause cancer. For more information, go to www.P65Warnings.ca.gov.

Citations for Mouse Erythropoietin/EPO Quantikine ELISA Kit

R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.

105 Citations: Showing 1 - 10
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  1. Iron chelation improves ineffective erythropoiesis and iron overload in myelodysplastic syndrome mice
    Authors: An, W;Feola, M;Levy, M;Aluri, S;Ruiz-Martinez, M;Sridharan, A;Fibach, E;Zhu, X;Verma, A;Ginzburg, Y;
    eLife
    Species: Mouse
    Sample Types: Serum
  2. Iron overload induces dysplastic erythropoiesis and features of myelodysplasia in Nrf2-deficient mice
    Authors: Duarte, TL;Lopes, M;Oliveira, M;Santos, AG;Vasco, C;Reis, JP;Antunes, AR;Gonçalves, A;Chacim, S;Oliveira, C;Porto, B;Teles, MJ;Moreira, AC;Silva, AMN;Schwessinger, R;Drakesmith, H;Henrique, R;Porto, G;Duarte, D;
    Leukemia
    Species: Mouse
    Sample Types: Serum
  3. PEGylated thrombopoietin mimetic, JNJ?26366821 a novel prophylactic radiation countermeasure for acute radiation injury
    Authors: Holmes-Hampton, GP;Kumar, VP;Biswas, S;Stone, S;Sharma, NK;Legesse, B;Vercellino, J;Guha, C;Eichenbaum, G;Ghosh, SP;
    Scientific reports
    Species: Mouse
    Sample Types: Serum
  4. Mitapivat reprograms red cell metabolome and improves anemia in a mouse model of hereditary spherocytosis
    Authors: Matte, A;Wilson, AB;Gevi, F;Federti, E;Recchiuti, A;Ferri, G;Brunati, AM;Pagano, MA;Russo, R;Leboeuf, C;Janin, A;Timperio, AM;Iolascon, A;Gremese, E;Dang, L;Mohandas, N;Brugnara, C;De Franceschi, L;
    JCI insight
    Species: Transgenic Mouse, Mouse
    Sample Types: Plasma
  5. EpoR Activation Stimulates Erythroid Precursor Proliferation by Inducing Phosphorylation of Tyrosine-88 of the CDK-Inhibitor p27Kip1
    Authors: Pegka, F;Ben-Califa, N;Neumann, D;Jäkel, H;Hengst, L;
    Cells
    Species: Mouse
    Sample Types: Plasma
  6. RNAi-mediated rheostat for dynamic control of AAV-delivered transgenes
    Authors: M Subramania, J McIninch, I Zlatev, MK Schlegel, C Kaittanis, T Nguyen, S Agarwal, T Racie, MA Alvarado, K Wassarman, TS Collins, T Chickering, CR Brown, K Schmidt, AB Castoreno, S Shulga-Mor, E Stamenova, K Buckowing, D Berman, JD Barry, A Bisbe, MA Maier, K Fitzgerald, V Jadhav
    Nature Communications, 2023-04-08;14(1):1970.
    Species: Mouse
    Sample Types: Serum
  7. Indoxyl sulfate impairs erythropoiesis at BFU-E stage in chronic kidney disease
    Authors: E Hamza, M Vallejo-Mu, H Ouled-Hadd, C García-Cab, M Guerrero-H, L Santier, S Rayego-Mat, IA Larabi, JC Alvarez, L Garçon, ZA Massy, G Choukroun, JA Moreno, L Metzinger, VM Meuth
    Cellular Signalling, 2022-12-31;0(0):110583.
    Species: Mouse
    Sample Types: Serum
  8. VHL-recruiting PROTAC attenuates renal fibrosis and preserves renal function via simultaneous degradation of Smad3 and stabilization of HIF-2alpha
    Authors: J Yang, Y Ruan, D Wang, J Fan, N Luo, H Chen, X Li, W Chen, X Wang
    Cell & bioscience, 2022-12-19;12(1):203.
    Species: Mouse
    Sample Types: Serum
  9. Pre-Administration of PLX-R18 Cells Protects Mice from Radiation-Induced Hematopoietic Failure and Lethality
    Authors: VP Kumar, S Biswas, GP Holmes-Ham, M Sheleg, S Stone, B Legesse, R Ofir, SP Ghosh
    Genes, 2022-09-28;13(10):.
    Species: Mouse
    Sample Types: Serum
  10. Contribution of HIF-P4H isoenzyme inhibition to metabolism indicates major beneficial effects being conveyed by HIF-P4H-2 antagonism
    Authors: J Tapio, R Halmetoja, EY Dimova, JM Mäki, A Laitala, G Walkinshaw, J Myllyharju, R Serpi, P Koivunen
    The Journal of Biological Chemistry, 2022-07-01;0(0):102222.
    Species: Mouse
    Sample Types: Serum
  11. Hypoxia ameliorates maternal diet-induced insulin resistance during pregnancy while having a detrimental effect on the placenta
    Authors: N Sissala, E Myllymäki, F Mohr, R Halmetoja, P Kuvaja, EY Dimova, P Koivunen
    Physiological Reports, 2022-05-01;10(9):e15302.
    Species: Mouse
    Sample Types: Serum
  12. Renoprotective effects of ferric citrate in a mouse model of chronic kidney disease
    Authors: MR Hanudel, B Czaya, S Wong, G Jung, K Chua, B Qiao, V Gabayan, T Ganz
    Scientific Reports, 2022-04-23;12(1):6695.
    Species: Mouse
    Sample Types:
  13. The microbiota regulates hematopoietic stem cell fate decisions by controlling iron availability in bone marrow
    Authors: D Zhang, X Gao, H Li, DK Borger, Q Wei, E Yang, C Xu, S Pinho, PS Frenette
    Cell Stem Cell, 2022-01-21;0(0):.
    Species: Mouse
    Sample Types: Bone Marrow Fluid
  14. Bone marrow sinusoidal endothelium controls terminal erythroid differentiation and reticulocyte maturation
    Authors: J Heil, V Olsavszky, K Busch, K Klapproth, C de la Torr, C Sticht, K Sandorski, J Hoffmann, H Schönhaber, J Zierow, M Winkler, CD Schmid, T Staniczek, DE Daniels, J Frayne, G Metzgeroth, D Nowak, S Schneider, M Neumaier, V Weyer, C Groden, HJ Gröne, K Richter, C Mogler, MM Taketo, K Schledzews, C Géraud, S Goerdt, PS Koch
    Nature Communications, 2021-11-29;12(1):6963.
    Species: Mouse
    Sample Types: Plasma
  15. Transforming growth factor-beta1 decreases erythropoietin production through repressing hypoxia-inducible factor 2alpha in erythropoietin-producing cells
    Authors: HM Shih, SY Pan, CJ Wu, YH Chou, CY Chen, FC Chang, YT Chen, WC Chiang, HC Tsai, YM Chen, SL Lin
    Journal of Biomedical Science, 2021-11-02;28(1):73.
    Species: Mouse
    Sample Types: Cell Culture Supernates
  16. Hypoxic preconditioning protects against ischemic kidney injury through the IDO1/kynurenine pathway
    Authors: R Torosyan, S Huang, PV Bommi, R Tiwari, SY An, M Schonfeld, G Rajendran, MA Kavanaugh, B Gibbs, AD Truax, S Bohney, MW Calcutt, EW Kerr, R Leonardi, P Gao, NS Chandel, PP Kapitsinou
    Cell Reports, 2021-08-17;36(7):109547.
    Species: Mouse
    Sample Types: Serum
  17. Yippee like 4 (Ypel4) is essential for normal mouse red blood cell membrane integrity
    Authors: A Mattebo, T Sen, M Jassinskaj, K Pimková, I Prieto Gon, AG Alattar, R Ramakrishn, S Lang, M Järås, J Hansson, S Soneji, S Singbrant, E van den Ak, J Flygare
    Scientific Reports, 2021-08-05;11(1):15898.
    Species: Mouse
    Sample Types: Serum
  18. Regulated control of gene therapies by drug-induced splicing
    Authors: AM Monteys, AA Hundley, PT Ranum, L Tecedor, A Muehlmatt, E Lim, D Lukashev, R Sivasankar, BL Davidson
    Nature, 2021-07-28;0(0):.
    Species: Mouse
    Sample Types: Plasma
  19. Early life stress induces dysregulation of the heme pathway in adult mice
    Authors: YD Pettway, TH Neder, DH Ho, BM Fox, M Burch, J Colson, X Liu, CE Kellum, KA Hyndman, JS Pollock
    Physiological Reports, 2021-05-01;9(10):e14844.
    Species: Mouse
    Sample Types: Plasma
  20. Experimental modulation of Interleukin 1 shows its key role in chronic kidney disease progression and anemia
    Authors: I Bandach, Y Segev, D Landau
    Scientific Reports, 2021-03-18;11(1):6288.
    Species: Mouse
    Sample Types: Serum
  21. Facilitative lysosomal transport of bile acids alleviates ER stress in mouse hematopoietic precursors
    Authors: AK Persaud, S Nair, MF Rahman, R Raj, B Weadick, D Nayak, C McElroy, M Shanmugam, S Knoblaugh, X Cheng, R Govindaraj
    Nature Communications, 2021-02-23;12(1):1248.
    Species: Mouse
    Sample Types: Plasma
  22. C-FGF23 peptide alleviates hypoferremia during acute inflammation
    Authors: R Agoro, MY Park, C Le Henaff, S Jankauskas, A Gaias, G Chen, M Mohammadi, D Sitara
    Haematologica, 2021-02-01;0(0):.
    Species: Mouse
    Sample Types: Serum
  23. Dysregulation of erythropoiesis and altered erythroblastic NMDA receptor-mediated calcium influx in Lrfn2-deficient mice
    Authors: R Maekawa, H Muto, M Hatayama, J Aruga
    PLoS ONE, 2021-01-22;16(1):e0245624.
    Species: Mouse
    Sample Types: Serum
  24. Bisphosphoglycerate Mutase Deficiency Protects against Cerebral Malaria and Severe Malaria-Induced Anemia
    Authors: G Xu, R van Brugge, CO Gualtieri, N Moradin, A Fois, D Vallerand, M De Sa Tava, A Bassenden, W Lu, M Tam, S Lesage, H Girouard, DZ Avizonis, G Deblois, JT Prchal, M Stevenson, A Berghuis, T Muir, J Rabinowitz, SM Vidal, N Fodil, P Gros
    Cell Rep, 2020-09-22;32(12):108170.
    Species: Mouse
    Sample Types: Serum
  25. Development of insulin resistance preceded major changes in iron homeostasis in mice fed a high-fat diet
    Authors: J Varghese, JV James, R Anand, M Narayanasa, G Rebekah, B Ramakrishn, AJ Nellickal, M Jacob
    J. Nutr. Biochem., 2020-06-02;84(0):108441.
    Species: Mouse
    Sample Types: Serum
  26. Erythropoietin and a hypoxia-inducible factor prolyl hydroxylase inhibitor (HIF-PHDi) lowers FGF23 in a model of chronic kidney disease (CKD)
    Authors: ML Noonan, EL Clinkenbea, P Ni, EA Swallow, SP Tippen, R Agoro, MR Allen, KE White
    Physiol Rep, 2020-06-01;8(11):e14434.
    Species: Mouse
    Sample Types: Serum
  27. microRNA and Metabolite Signatures Linked to Early Consequences of Lethal Radiation
    Authors: N Chakrabort, A Gautam, GP Holmes-Ham, VP Kumar, S Biswas, R Kumar, D Hamad, G Dimitrov, AO Olabisi, R Hammamieh, SP Ghosh
    Sci Rep, 2020-03-25;10(1):5424.
    Species: Mouse
    Sample Types: Serum
  28. Acai Extract Transiently Upregulates Erythropoietin by Inducing a Renal Hypoxic Condition in Mice
    Authors: S Shibuya, T Toda, Y Ozawa, MJV Yata, T Shimizu
    Nutrients, 2020-02-19;12(2):.
    Species: Mouse
    Sample Types: Plasma
  29. Dysregulated mesenchymal PDGFR-&beta drives kidney fibrosis
    Authors: EM Buhl, S Djudjaj, BM Klinkhamme, K Ermert, VG Puelles, MT Lindenmeye, CD Cohen, C He, E Borkham-Ka, R Weiskirche, B Denecke, P Trairatphi, J Saez-Rodri, TB Huber, LE Olson, J Floege, P Boor
    EMBO Mol Med, 2020-01-14;0(0):e11021.
    Species: Mouse
    Sample Types: Serum
  30. A substitution mutation in a conserved domain of mammalian acetate-dependent acetyl CoA synthetase 2 results in destabilized protein and impaired HIF-2 signaling.
    Authors: Nagati J, Xu M, Garcia T, Comerford S, Hammer R, Garcia J
    PLoS ONE, 2019-11-14;14(11):e0225105.
    Species: Mouse
    Sample Types: Serum
  31. Minihepcidins improve ineffective erythropoiesis and splenomegaly in a new mouse model of adult beta-thalassemia major
    Authors: C Casu, R Chessa, A Liu, R Gupta, H Drakesmith, R Fleming, YZ Ginzburg, B MacDonald, S Rivella
    Haematologica, 2019-10-03;0(0):.
    Species: Mouse
    Sample Types: Serum
  32. Glutathione peroxidase 4 and vitamin E control reticulocyte maturation, stress erythropoiesis and iron homeostasis
    Authors: S Altamura, NM Vegi, PS Hoppe, T Schroeder, M Aichler, A Walch, K Okreglicka, L Hültner, M Schneider, C Ladinig, C Kuklik-Roo, J Mysliwietz, D Janik, F Neff, B Rathkolb, M Hrabé de A, C Buske, AR da Silva, K Muedder, M Conrad, T Ganz, M Kopf, MU Muckenthal, GW Bornkamm
    Haematologica, 2019-06-27;0(0):.
    Species: Mouse
    Sample Types: Plasma
  33. Oral Gavage of Ginger Nanoparticle-Derived Lipid Vectors Carrying Dmt1 siRNA Blunts Iron Loading in Murine Hereditary Hemochromatosis
    Authors: X Wang, M Zhang, SRL Flores, RR Woloshun, C Yang, L Yin, P Xiang, X Xu, MD Garrick, S Vidyasagar, D Merlin, JF Collins
    Mol. Ther., 2019-01-12;0(0):.
    Species: Mouse
    Sample Types: Plasma
  34. Dosage time affects alkylating agents induced micronuclei in mouse peripheral blood reticulocytes through the function of erythropoietin
    Authors: K Itoh, S Masumori, D Mukai, H Sakakibara, M Yasuda, K Shimoi
    J Toxicol Sci, 2019-01-01;44(4):273-282.
    Species: Mouse
    Sample Types: Plasma
  35. Multi-Walled Carbon Nanotubes Augment Allergic Airway Eosinophilic Inflammation by Promoting Cysteinyl Leukotriene Production
    Authors: S Carvalho, M Ferrini, L Herritt, A Holian, Z Jaffar, K Roberts
    Front Pharmacol, 2018-06-05;9(0):585.
    Species: Mouse
    Sample Types: BALF
  36. Different effects of granulocyte colony-stimulating factor and erythropoietin on erythropoiesis
    Authors: TL Chen, YW Chiang, GL Lin, HH Chang, TS Lien, MH Sheh, DS Sun
    Stem Cell Res Ther, 2018-05-02;9(1):119.
    Species: Mouse
    Sample Types: Serum
  37. Inhibition of fibroblast growth factor 23 (FGF23) signaling rescues renal anemia
    Authors: R Agoro, A Montagna, R Goetz, O Aligbe, G Singh, LM Coe, M Mohammadi, S Rivella, D Sitara
    FASEB J., 2018-02-26;0(0):fj201700667R.
    Species: Mouse
    Sample Types: Serum
  38. FGF23 expression in rodents is directly induced via erythropoietin after inhibition of hypoxia inducible factor proline hydroxylase
    Authors: I Flamme, P Ellinghaus, D Urrego, T Krüger
    PLoS ONE, 2017-10-26;12(10):e0186979.
    Species: Rat
    Sample Types: Plasma
  39. Clostridium perfringens ?-toxin impairs erythropoiesis by inhibition of erythroid differentiation
    Authors: T Takagishi, M Takehara, S Seike, K Miyamoto, K Kobayashi, M Nagahama
    Sci Rep, 2017-07-12;7(1):5217.
    Species: Mouse
    Sample Types: Plasma
  40. The protective role of TET2 in erythroid iron homeostasis against oxidative stress and erythropoiesis
    Authors: S Guo, X Jiang, Y Wang, L Chen, H Li, X Li, Y Jia
    Cell. Signal., 2017-07-08;38(0):106-115.
    Species: Mouse
    Sample Types: Serum
  41. Activation of Hypoxia Signaling in Stromal Progenitors Impairs Kidney Development
    Authors: K Gerl, D Steppan, M Fuchs, C Wagner, C Willam, A Kurtz, B Kurt
    Am. J. Pathol., 2017-05-17;0(0):.
    Species: Mouse
    Sample Types: Plasma
  42. A novel indole compound MA-35 attenuates renal fibrosis by inhibiting both TNF-? and TGF-?1 pathways
    Authors: H Shima, K Sasaki, T Suzuki, C Mukawa, T Obara, Y Oba, A Matsuo, T Kobayashi, E Mishima, S Watanabe, Y Akiyama, K Kikuchi, T Matsuhashi, Y Oikawa, F Nanto, Y Akiyama, HJ Ho, C Suzuki, D Saigusa, A Masamune, Y Tomioka, T Masaki, S Ito, KI Hayashi, T Abe
    Sci Rep, 2017-05-15;7(1):1884.
    Species: Mouse
    Sample Types: Plasma
  43. Deletion of Stk40 impairs definitive erythropoiesis in the mouse fetal liver
    Authors: L Wang, H Yu, H Cheng, K He, Z Fang, L Ge, T Cheng, Y Jin
    Cell Death Dis, 2017-03-30;8(3):e2722.
    Species: Mouse
    Sample Types: Plasma
  44. Induction of erythropoiesis by hypoxia-inducible factor prolyl hydroxylase inhibitors without promotion of tumor initiation, progression, or metastasis in a VEGF-sensitive model of spontaneous breast cancer
    Authors: TW Seeley, MD Sternlicht, SJ Klaus, TB Neff, DY Liu
    Hypoxia (Auckl), 2017-03-10;5(0):1-9.
    Species: Mouse
    Sample Types: Plasma
  45. Iron suppresses erythropoietin expression via oxidative stress-dependent hypoxia-inducible factor-2 alpha inactivation
    Authors: K Oshima, Y Ikeda, Y Horinouchi, H Watanabe, H Hamano, Y Kihira, S Kishi, Y Izawa-Ishi, L Miyamoto, T Hirayama, H Nagasawa, K Ishizawa, K Tsuchiya, T Tamaki
    Lab. Invest, 2017-03-06;0(0):.
    Species: Mouse
    Sample Types: Plasma
  46. Protective effect of maternal uteroplacental insufficiency on oxygen-induced retinopathy in offspring: removing bias of premature birth
    Authors: S Becker, H Wang, B Yu, R Brown, X Han, RH Lane, ME Hartnett
    Sci Rep, 2017-02-14;7(0):42301.
    Species: Rat
    Sample Types: Serum
  47. Renal Anemia Model Mouse Established by Transgenic Rescue with Erythropoietin Gene Lacking Kidney-specific Regulatory Elements
    Mol. Cell. Biol, 2017-02-01;0(0):.
    Species: Mouse
    Sample Types: Plasma
  48. Notch downregulation and extramedullary erythrocytosis in HIF prolyl 4-hydroxylase-2-deficient mice
    Mol. Cell. Biol., 2017-01-04;0(0):.
    Species: Mouse
    Sample Types: Serum
  49. Hypoxia sensing through ?-adrenergic receptors
    JCI Insight, 2016-12-22;1(21):e90240.
    Species: Mouse
    Sample Types: Serum
  50. Human CD133(+) Renal Progenitor Cells Induce Erythropoietin Production and Limit Fibrosis After Acute Tubular Injury
    Sci Rep, 2016-11-17;6(0):37270.
    Species: Mouse
    Sample Types: Plasma
  51. Salmonella infection enhances erythropoietin production by the kidney and liver correlating with elevated bacterial burdens
    Infect Immun, 2016-09-19;0(0):.
    Species: Mouse
    Sample Types: Serum
  52. Improved Human Erythropoiesis and Platelet Formation in Humanized NSGW41 Mice
    Stem Cell Reports, 2016-09-08;0(0):.
    Species: Mouse
    Sample Types: Plasma
  53. The Zinc Finger of Prolyl Hydroxylase Domain Protein 2 is Essential for Efficient Hydroxylation of Hypoxia Inducible Factor-?
    Authors: Patrick R Arsenault
    Mol Cell Biol, 2016-08-26;0(0):.
    Species: Mouse
    Sample Types: Serum
  54. Phagocyte respiratory burst activates macrophage erythropoietin signalling to promote acute inflammation resolution
    Nat Commun, 2016-07-11;7(0):12177.
    Species: Mouse
    Sample Types: Peritoneal Fluid
  55. Comparative systems pharmacology of HIF stabilization in the prevention of retinopathy of prematurity
    Authors: G Hoppe, S Yoon, B Gopalan, AR Savage, R Brown, K Case, A Vasanji, ER Chan, RB Silver, JE Sears
    Proc Natl Acad Sci USA, 2016-04-18;0(0):.
    Species: Mouse
    Sample Types: Serum
  56. The Mitochondrial Respiratory Chain Is Required for Organismal Adaptation to Hypoxia
    Authors: RB Hamanaka, SE Weinberg, CR Reczek, NS Chandel
    Cell Rep, 2016-04-07;15(3):451-9.
    Species: Mouse
    Sample Types: Serum
  57. Hypercapnia suppresses the HIF-dependent adaptive response to hypoxia
    Authors: AC Selfridge, MA Cavadas, CC Scholz, EL Campbell, LC Welch, E Lecuona, SP Colgan, KE Barrett, PH Sporn, JI Sznajder, EP Cummins, CT Taylor
    J Biol Chem, 2016-04-04;0(0):.
    Species: Mouse
    Sample Types: Serum
  58. Mice with a Mutation in the Mdm2 Gene That Interferes with MDM2/Ribosomal Protein Binding Develop a Defect in Erythropoiesis
    Authors: T Kamio, BW Gu, TS Olson, Y Zhang, PJ Mason, M Bessler
    PLoS ONE, 2016-04-04;11(4):e0152263.
    Species: Mouse
    Sample Types: Serum
  59. Glutathione peroxidase 4 prevents necroptosis in mouse erythroid precursors.
    Authors: Canli O, Alankus Y, Grootjans S, Vegi N, Hultner L, Hoppe P, Schroeder T, Vandenabeele P, Bornkamm G, Greten F
    Blood, 2015-10-13;127(1):139-48.
    Species: Mouse
    Sample Types: Serum
  60. Mimicking hypoxia to treat anemia: HIF-stabilizer BAY 85-3934 (Molidustat) stimulates erythropoietin production without hypertensive effects.
    Authors: Flamme I, Oehme F, Ellinghaus P, Jeske M, Keldenich J, Thuss U
    PLoS ONE, 2014-11-13;9(11):e111838.
    Species: Rat
    Sample Types: Plasma
  61. Conditional disruption of the prolyl hydroxylase domain-containing protein 2 (Phd2) gene defines its key role in skeletal development.
    Authors: Cheng S, Xing W, Pourteymoor S, Mohan S
    J Bone Miner Res, 2014-10-01;29(10):2276-86.
    Species: Mouse
    Sample Types: Serum
  62. Transgene regulation using the tetracycline-inducible TetR-KRAB system after AAV-mediated gene transfer in rodents and nonhuman primates.
    Authors: Le Guiner C, Stieger K, Toromanoff A, Guilbaud M, Mendes-Madeira A, Devaux M, Guigand L, Cherel Y, Moullier P, Rolling F, Adjali O
    PLoS ONE, 2014-09-23;9(9):e102538.
    Species: Mouse
    Sample Types: Serum
  63. Rasa3 controls megakaryocyte Rap1 activation, integrin signaling and differentiation into proplatelet.
    Authors: Molina-Ortiz P, Polizzi S, Ramery E, Gayral S, Delierneux C, Oury C, Iwashita S, Schurmans S
    PLoS Genet, 2014-06-26;10(6):e1004420.
    Species: Mouse
    Sample Types: Serum
  64. Inducing a visceral organ to protect a peripheral capillary bed: stabilizing hepatic HIF-1alpha prevents oxygen-induced retinopathy.
    Authors: Hoppe G, Lee T, Yoon S, Yu M, Peachey N, Rayborn M, Zutel M, Trichonas G, Au J, Sears J
    Am J Pathol, 2014-04-13;184(6):1890-9.
    Species: Mouse
    Sample Types: Serum
  65. An activin receptor IIA ligand trap corrects ineffective erythropoiesis in beta-thalassemia.
    Authors: Dussiot M, Maciel T, Fricot A, Chartier C, Negre O, Veiga J, Grapton D, Paubelle E, Payen E, Beuzard Y, Leboulch P, Ribeil J, Arlet J, Cote F, Courtois G, Ginzburg Y, Daniel T, Chopra R, Sung V, Hermine O, Moura I
    Nat Med, 2014-03-23;20(4):398-407.
    Species: Mouse
    Sample Types: Serum
  66. The erythroid function of transferrin receptor 2 revealed by Tmprss6 inactivation in different models of transferrin receptor 2 knockout mice.
    Authors: Nai A, Pellegrino R, Rausa M, Pagani A, Boero M, Silvestri L, Saglio G, Roetto A, Camaschella C
    Haematologica, 2014-03-21;99(6):1016-21.
    Species: Mouse
    Sample Types: Serum
  67. An activin receptor IIA ligand trap promotes erythropoiesis resulting in a rapid induction of red blood cells and haemoglobin.
    Authors: Carrancio S, Markovics J, Wong P, Leisten J, Castiglioni P, Groza M, Raymon H, Heise C, Daniel T, Chopra R, Sung V
    Br J Haematol, 2014-03-18;165(6):870-82.
    Species: Mouse
    Sample Types: Plasma
  68. Ciprofloxacin enhances stress erythropoiesis in spleen and increases survival after whole-body irradiation combined with skin-wound trauma.
    Authors: Fukumoto R, Burns T, Kiang J
    PLoS ONE, 2014-02-28;9(2):e90448.
    Species: Mouse
    Sample Types: Serum
  69. FGF-23 is a negative regulator of prenatal and postnatal erythropoiesis.
    Authors: Coe, Lindsay, Madathil, Sangeeth, Casu, Carla, Lanske, Beate, Rivella, Stefano, Sitara, Despina
    J Biol Chem, 2014-02-07;289(14):9795-810.
    Species: Mouse
    Sample Types: Serum
  70. Erythropoietin guides multipotent hematopoietic progenitor cells toward an erythroid fate.
    Authors: Grover, Amit, Mancini, Elena, Moore, Susan, Mead, Adam J, Atkinson, Deborah, Rasmussen, Kasper D, O'Carroll, Donal, Jacobsen, Sten Eir, Nerlov, Claus
    J Exp Med, 2014-02-03;211(2):181-8.
    Species: Mouse
    Sample Types: Serum
  71. Klotho deficiency disrupts hematopoietic stem cell development and erythropoiesis.
    Authors: Vadakke Madathil S, Coe L, Casu C, Sitara D
    Am J Pathol, 2014-01-08;184(3):827-41.
    Species: Mouse
    Sample Types: Serum
  72. Chronic psychological stress activates BMP4-dependent extramedullary erythropoiesis.
    Authors: Vignjevic S, Budec M, Markovic D, Dikic D, Mitrovic O, Mojsilovic S, Duric S, Koko V, Cokic B, Cokic V, Jovcic G
    J Cell Mol Med, 2013-11-27;18(1):91-103.
    Species: Mouse
    Sample Types: Plasma
  73. A knock-in mouse model of human PHD2 gene-associated erythrocytosis establishes a haploinsufficiency mechanism.
    Authors: Arsenault, Patrick, Pei, Fei, Lee, Rebecca, Kerestes, Heddy, Percy, Melanie, Keith, Brian, Simon, M Celest, Lappin, Terence, Khurana, Tejvir S, Lee, Frank S
    J Biol Chem, 2013-10-11;288(47):33571-84.
    Species: Mouse
    Sample Types: Serum
  74. Impaired in vitro erythropoiesis following deletion of the Scl (Tal1) +40 enhancer is largely compensated for in vivo despite a significant reduction in expression.
    Authors: Ferreira R, Spensberger D, Silber Y, Dimond A, Li J, Green A, Gottgens B
    Mol Cell Biol, 2013-01-14;33(6):1254-66.
    Species: Mouse
    Sample Types: Serum
  75. EPO-mediated expansion of late-stage erythroid progenitors in the bone marrow initiates recovery from sublethal radiation stress.
    Authors: Peslak, Scott A, Wenger, Jesse, Bemis, Jeffrey, Kingsley, Paul D, Koniski, Anne D, McGrath, Kathleen, Palis, James
    Blood, 2012-08-13;120(12):2501-11.
    Species: Mouse
    Sample Types: Plasma
  76. Exogenous erythropoietin administration attenuates intermittent hypoxia-induced cognitive deficits in a murine model of sleep apnea.
    BMC Neurosci, 2012-07-03;13(0):77.
    Species: Mouse
    Sample Types: Tissue Homogenates
  77. Treatment of erythropoietin deficiency in mice with systemically administered siRNA.
    Authors: Querbes, William, Bogorad, Roman L, Moslehi, Javid, Wong, Jamie, Chan, Amy Y, Bulgakova, Elena, Kuchimanchi, Satya, Akinc, Akin, Fitzgerald, Kevin, Koteliansky, Victor, Kaelin, William
    Blood, 2012-05-18;120(9):1916-22.
    Species: Mouse
    Sample Types: Serum
  78. General anesthetics inhibit erythropoietin induction under hypoxic conditions in the mouse brain.
    Authors: Tanaka T, Kai S, Koyama T, Daijo H, Adachi T, Fukuda K, Hirota K
    PLoS ONE, 2011-12-27;6(12):e29378.
    Species: Mouse
    Sample Types: Tissue Homogenates
  79. Aconitase Regulation of Erythropoiesis Correlates with a Novel Licensing Function in Erythropoietin-Induced ERK Signaling.
    Authors: Talbot AL, Bullock GC, Delehanty LL
    PLoS ONE, 2011-08-22;6(8):e23850.
    Species: Mouse
    Sample Types: Serum
  80. 3'UTR-truncated Hmga2 cDNA causes MPN-like hematopoiesis by conferring a clonal growth advantage at the level of HSC in mice.
    Authors: Ikeda K, Mason PJ, Bessler M
    Blood, 2011-04-01;117(22):5860-9.
    Species: Mouse
    Sample Types: Serum
  81. A mouse model of hereditary folate malabsorption: deletion of the PCFT gene leads to systemic folate deficiency.
    Authors: Salojin KV, Cabrera RM, Sun W
    Blood, 2011-02-23;117(18):4895-904.
    Species: Mouse
    Sample Types: Serum
  82. A postweaning iron-adequate diet following neonatal iron deficiency affects iron homeostasis and growth in young rats.
    Authors: Hegde NV, Jensen GL, Unger EL
    J. Nutr., 2011-01-05;141(3):386-90.
    Species: Rat
    Sample Types: Serum
  83. Innate immune activation during Salmonella infection initiates extramedullary erythropoiesis and splenomegaly.
    Authors: Jackson A, Nanton MR, O'Donnell H
    J. Immunol., 2010-10-15;185(10):6198-204.
    Species: Mouse
    Sample Types: Serum
  84. Minimal doses of a sequence-optimized transgene mediate high-level and long-term EPO expression in vivo: challenging CpG-free gene design.
    Authors: Kosovac D, Wild J, Ludwig C, Meissner S, Bauer AP, Wagner R
    Gene Ther., 2010-10-14;18(2):189-98.
    Species: Mouse
    Sample Types: Serum
  85. JAK2 V617F impairs hematopoietic stem cell function in a conditional knock-in mouse model of JAK2 V617F-positive essential thrombocythemia.
    Authors: Li J, Spensberger D, Ahn JS
    Blood, 2010-05-20;116(9):1528-38.
    Species: Mouse
    Sample Types: Plasma
  86. Cellular and molecular mechanisms regulating the hepatic erythropoietin expression during acute-phase response: a role for IL-6.
    Authors: Ramadori P, Ahmad G, Ramadori G
    Lab. Invest., 2010-05-10;90(9):1306-24.
    Species: Mouse
    Sample Types: Serum
  87. Therapeutic levels of erythropoietin (EPO) achieved after gene electrotransfer to skin in mice.
    Authors: Gothelf A, Hojman P, Gehl J
    Gene Ther., 2010-04-22;17(9):1077-84.
    Species: Mouse
    Sample Types: Serum
  88. AMPKalpha1 deletion shortens erythrocyte life span in mice: role of oxidative stress.
    Authors: Wang S, Dale GL, Song P
    J. Biol. Chem., 2010-04-14;285(26):19976-85.
    Species: Mouse
    Sample Types: Plasma
  89. Role for parasite genetic diversity in differential host responses to Trypanosoma brucei infection.
    Authors: Morrison LJ, McLellan S, Sweeney L, Chan CN, MacLeod A, Tait A, Turner CM
    Infect. Immun., 2010-01-19;78(3):1096-108.
    Species: Mouse
    Sample Types: Plasma
  90. The glial cell response is an essential component of hypoxia-induced erythropoiesis in mice.
    Authors: Weidemann A, Kerdiles YM, Knaup KX, Rafie CA, Boutin AT, Stockmann C, Takeda N, Scadeng M, Shih AY, Haase VH, Simon MC, Kleinfeld D, Johnson RS
    J. Clin. Invest., 2009-10-05;119(11):3373-83.
    Species: Mouse
    Sample Types: Plasma
  91. Rescue of pyruvate kinase deficiency in mice by gene therapy using the human isoenzyme.
    Authors: Meza NW, Alonso-Ferrero ME, Navarro S, Quintana-Bustamante O, Valeri A, Garcia-Gomez M, Bueren JA, Bautista JM, Segovia JC
    Mol. Ther., 2009-09-15;17(12):2000-9.
    Species: Mouse
    Sample Types: Plasma
  92. Hyperoxia disrupts vascular endothelial growth factor-nitric oxide signaling and decreases growth of endothelial colony-forming cells from preterm infants.
    Authors: Fujinaga H, Baker CD, Ryan SL, Markham NE, Seedorf GJ, Balasubramaniam V, Abman SH
    Am. J. Physiol. Lung Cell Mol. Physiol., 2009-09-04;297(6):L1160-9.
    Species: Mouse
    Sample Types: Serum
  93. Short-term effects of pharmacologic HIF stabilization on vasoactive and cytotrophic factors in developing mouse brain.
    Authors: Schneider C, Krischke G, Keller S, Walkinshaw G, Arend M, Rascher W, Gassmann M, Trollmann R
    Brain Res., 2009-05-18;1280(0):43-51.
    Species: Mouse
    Sample Types: Serum
  94. HIF-2alpha, but not HIF-1alpha, promotes iron absorption in mice.
    Authors: Mastrogiannaki M, Matak P, Keith B, Simon MC, Vaulont S, Peyssonnaux C
    J. Clin. Invest., 2009-04-06;119(5):1159-66.
    Species: Mouse
    Sample Types: Serum
  95. Stat5 regulates cellular iron uptake of erythroid cells via IRP-2 and TfR-1.
    Authors: Kerenyi MA, Grebien F, Gehart H, Schifrer M, Artaker M, Kovacic B, Beug H, Moriggl R, Mullner EW
    Blood, 2008-08-11;112(9):3878-88.
    Species: Mouse
    Sample Types: Serum
  96. Epidermal sensing of oxygen is essential for systemic hypoxic response.
    Authors: Boutin AT, Weidemann A, Fu Z, Mesropian L, Gradin K, Jamora C, Wiesener M, Eckardt KU, Koch CJ, Ellies LG, Haddad G, Haase VH, Simon MC, Poellinger L, Powell FL, Johnson RS
    Cell, 2008-04-18;133(2):223-34.
    Species: Mouse
    Sample Types: Plasma
  97. n-Propyl gallate activates hypoxia-inducible factor 1 by modulating intracellular oxygen-sensing systems.
    Authors: Kimura M, Takabuchi S, Tanaka T, Murata M, Nishi K, Oda S, Oda T, Kanai M, Fukuda K, Kizaka-Kondoh S, Adachi T, Takabayashi A, Semenza GL, Hirota K
    Biochem. J., 2008-04-01;411(1):97-105.
    Species: Mouse
    Sample Types: Serum
  98. Transgenic expression of JAK2V617F causes myeloproliferative disorders in mice.
    Authors: Xing S, Wanting TH, Zhao W, Ma J, Wang S, Xu X, Li Q, Fu X, Xu M, Zhao ZJ
    Blood, 2008-03-11;111(10):5109-17.
    Species: Mouse
    Sample Types: Plasma
  99. Ratio of mutant JAK2-V617F to wild-type Jak2 determines the MPD phenotypes in transgenic mice.
    Authors: Tiedt R, Hao-Shen H, Sobas MA, Looser R, Dirnhofer S, Schwaller J, Skoda RC
    Blood, 2007-12-26;111(8):3931-40.
    Species: Mouse
    Sample Types: Plasma
  100. von Hippel-Lindau mutation in mice recapitulates Chuvash polycythemia via hypoxia-inducible factor-2alpha signaling and splenic erythropoiesis.
    Authors: Hickey MM, Lam JC, Bezman NA, Rathmell WK, Simon MC
    J. Clin. Invest., 2007-12-01;117(12):3879-3889.
    Species: Mouse
    Sample Types: Serum
  101. Multiple circulating proangiogenic factors induced by sunitinib malate are tumor-independent and correlate with antitumor efficacy.
    Authors: Ebos JM, Lee CR, Christensen JG, Mutsaers AJ, Kerbel RS
    Proc. Natl. Acad. Sci. U.S.A., 2007-10-17;104(43):17069-74.
    Species: Mouse
    Sample Types: Plasma
  102. Microcytosis in ank/ank mice and the role of ANKH in promoting erythroid differentiation.
    Authors: Wang J, Wang C, Tsui HW, Las Heras F, Cheng EY, Iscove NN, Chiu B, Inman RD, Pritzker KP, Tsui FW
    Exp. Cell Res., 2007-09-20;313(20):4120-9.
    Species: Mouse
    Sample Types: Serum
  103. Clostridium sordellii lethal toxin kills mice by inducing a major increase in lung vascular permeability.
    Authors: Geny B, Khun H, Fitting C, Zarantonelli L, Mazuet C, Cayet N, Szatanik M, Prevost MC, Cavaillon JM, Huerre M, Popoff MR
    Am. J. Pathol., 2007-03-01;170(3):1003-17.
    Species: Mouse
    Sample Types: Tissue Homogenates
  104. Suppression of hepcidin during anemia requires erythropoietic activity.
    Authors: Pak M, Lopez MA, Gabayan V, Ganz T, Rivera S
    Blood, 2006-08-01;108(12):3730-5.
    Species: Mouse
    Sample Types: Serum
  105. Somatic activation of a conditional KrasG12D allele causes ineffective erythropoiesis in vivo.
    Authors: Braun BS, Archard JA, Van Ziffle JA, Tuveson DA, Jacks TE, Shannon K
    Blood, 2006-05-23;108(6):2041-4.
    Species: Mouse
    Sample Types: Serum

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Mouse Erythropoietin/EPO Quantikine ELISA Kit
By Anonymous on 01/27/2024
Sample Tested: n/a,Serum
Mouse Erythropoietin/EPO Quantikine ELISA Kit MEP00B
Mouse Erythropoietin Quantikine ELISA Kit
By Leslie Priddy on 04/13/2018
Sample Tested: Serum
Mouse Erythropoietin Quantikine ELISA Kit
By Jeff Pimentel on 04/02/2018
Sample Tested: mouse serum
Mouse Erythropoietin Quantikine ELISA Kit
By Jakub Zmajkovic on 08/17/2017
Sample Tested: Plasma
Mouse Erythropoietin Quantikine ELISA Kit MEP00B