Mouse Frizzled-6 (AAH26150) VersaClone cDNA

Catalog #: RDC0122 Datasheet / COA / SDS

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RDC0122

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Mouse Frizzled-6 (AAH26150) VersaClone cDNA Summary

Specifications

Source

N/A

Shipping Conditions

The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.

Storage

Store the unopened product at -20 to -70 °C. Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Do not use past expiration date.

Species

Mouse

Product Datasheets

Product Datasheet

COA

SDS

Background: Frizzled-6

This group of G protein-coupled receptors consists of 10 structurally-related, seven transmembrane proteins with a divergent N-terminal signal peptide and a variable-length C-terminal tail. The Frizzled family proteins contain a highly conserved cysteine-rich domain and a variable length linker region. Frizzled proteins function as receptors for Wnt proteins and can activate canonical Wnt/beta-catenin signaling as well as non-canonical pathways (Planar Cell Polarity and Wnt/Ca²⁺Pathways). Wnt/Frizzled signaling is involved in a variety of developmental processes including cell fate determination, cell polarity, tissue patterning, and control of cell proliferation. Activation of a given Wnt/Frizzled signaling cascade is dependent on the Wnt ligand and the cell context. Frizzled proteins also form co-receptor complexes with LRP, ROR, and Ryk molecules.

Entrez Gene IDs

8323 (Human); 14368 (Mouse)

Alternate Names

frizzled (Drosophila) homolog 6; frizzled homolog 6 (Drosophila); Frizzled6; Frizzled-6; FZ6; fz-6; FZD6; Hfz6; seven transmembrane helix receptor