Mouse Glut2 APC-conjugated Antibody

Catalog #: FAB1440A
4 Citations Datasheet / COA / SDS

Catalog #	Availability	Size / Price	Qty
FAB1440A-100UG

Detection of Glut2 in beta TC‑6 Mouse Cell Line by Flow Cytometry.

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All Glut2 Antibodies

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Citations (4)

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Summary Data Examples Preparation and Storage Reconstitution Calculator Background Product Datasheets Related Research Areas

Mouse Glut2 APC-conjugated Antibody Summary

Species Reactivity

Mouse

Specificity

Detects mouse Glut2. Recognizes mouse Glut2-transfected NS0 cells but not NS0 control transfectants. It also detects Glut2 on mouse insulinoma beta TC-6 cells (1).

Source

Monoclonal Rat IgG_2B Clone # 205115

Purification

Protein A or G purified from hybridoma culture supernatant

Immunogen

CHO Chinese hamster ovary cell line transfected with mouse Glut2
Met1-Val523
Accession # P14246

Formulation

Supplied in a saline solution containing BSA and Sodium Azide.

Label

Allophycocyanin (Excitation= 620-650 nm, Emission= 660-670 nm)

Applications

Recommended Concentration

Sample

Flow Cytometry

0.25-1 µg/10⁶ cells

See below

Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.

Scientific Data

Flow Cytometry

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Detection of Glut2 in beta TC‑6 Mouse Cell Line by Flow Cytometry. beta TC-6 mouse beta cell insulinoma cell line was stained with Rat Anti-Mouse Glut2 APC-conjugated Monoclonal Antibody (Catalog # FAB1440A, filled histogram) or isotype control antibody (Catalog # IC013A, open histogram). View our protocol for Staining Membrane-associated Proteins.

Reconstitution Calculator

Preparation and Storage

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store the unopened product at 2 - 8° C. Do not use past expiration date. Protect from light.

Background: Glut2

Glut2, also known as SLC2A2, belongs to the facilitative glucose transporter protein family that comprises 13 members. It is an integral membrane glycoprotein with 12 transmembrane domains. Glut2 is expressed predominantly in liver, intestine, kidney and pancreatic beta-cells. It is a low-affinity glucose transporter that has been suggested to function as a glucose sensor in pancreatic beta-cells, and facilitate either glucose uptake or efflux from cells depending on the nutritional state (1, 2).

References

Poitout, V. et al. (1995) Diabetes 44:306.
Olson, A.L. and J.E. Pessin (1996) Annu. Rev. Nut. 16:235.

Long Name

Glucose Transporter Type 2

Entrez Gene IDs

6514 (Human); 20526 (Mouse)

Alternate Names

GLUT2 Glucose transporter type 2, liver; Glut2; GLUT-2; SLC2A2; solute carrier family 2 (facilitated glucose transporter), member 2; solute carrier family 2, facilitated glucose transporter member 2

Product Datasheets

Product Datasheet

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Related Research Areas

Citations for Mouse Glut2 APC-conjugated Antibody

R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.

4 Citations: Showing 1 - 4
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Metastatic pancreatic neuroendocrine tumors manifest elevated T cell infiltration
Authors: J Greenberg, J Limberg, A Verma, D Kim, X Chen, YJ Lee, MD Moore, TM Ullmann, JW Thiesmeyer, Z Loewenstei, KJ Chen, CE Egan, D Stefanova, R Bareja, R Zarnegar, BM Finnerty, T Scognamigl, YN Du, O Elemento, TJ Fahey Iii, IM Min
JCI Insight, 2022-12-08;0(0):.
Species: Mouse
Sample Types: Whole Cells
Applications: ICC
Transgenic Overexpression of Galectin-3 in Pancreatic beta Cells Attenuates Hyperglycemia in Mice: Synergistic Antidiabetic Effect With Exogenous IL-33
Authors: N Jovicic, I Petrovic, N Pejnovic, B Ljujic, M Miletic Ko, S Pavlovic, I Jeftic, A Djukic, I Srejovic, V Jakovljevi, ML Lukic
Frontiers in Pharmacology, 2021-11-05;12(0):714683.
Species: Mouse
Sample Types: Whole Cells
Applications: Flow Cytometry
Overexpression of Galectin 3 in Pancreatic beta Cells Amplifies beta -Cell Apoptosis and Islet Inflammation in Type-2 Diabetes in Mice
Authors: Ivica Petrovic, Nada Pejnovic, Biljana Ljujic, Sladjana Pavlovic, Marina Miletic Kovacevic, Ilija Jeftic et al.
Front Endocrinol (Lausanne)
Hepatic PTP4A1 ameliorates high-fat diet-induced hepatosteatosis and hyperglycemia by the activation of the CREBH/FGF21 axis
Authors: Byungtae Hwang, Min-Gi Kwon, Min Ji Cho, Nam-Kyung Lee, Jangwook Lee, Jeong Woong Lee et al.
Theranostics