Mouse IL-11 Biotinylated Antibody Summary
Gly23-Leu199
Accession # P47873
Applications
Mouse IL-11 Sandwich Immunoassay
Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.
Reconstitution Calculator
Preparation and Storage
- 12 months from date of receipt, -20 to -70 °C as supplied.
- 1 month, 2 to 8 °C under sterile conditions after reconstitution.
- 6 months, -20 to -70 °C under sterile conditions after reconstitution.
Background: IL-11
Interleukin-11 is a pleiotropic cytokine that was originally detected in the conditioned medium of an IL-1 alpha -stimulated primate bone marrow stromal cell line (PU-34) as a mitogen for the IL-6-responsive murine plasmacytoma cell line T1165. IL-11 was also independently discovered as an adipogenesis inhibitory factor (AGIF). The mouse IL-11 cDNA encodes a 199 amino acid residue precursor polypeptide with a 22 amino acid residue hydrophobic signal that is processed proteolytically to generate the 177 amino acid residue mature protein. IL-11 contains no cysteine residues or potential glycosylation sites.
IL-11 has multiple effects on both hematopoietic and nonhematopoietic cells. Many of the biological effects described for IL-11 overlap those for IL-6. In vitro, IL-11 can synergize with IL-3, IL-4 and SCF to shorten the G0 period of early hematopoietic progenitors. IL-11 also enhances the IL-3-dependent megakaryocyte colony formation. IL-11 has been found to stimulate the T cell dependent development of specific immunoglobulin-secreting B cells. IL-11, in the presence of IL-3 or SCF, has also been shown to stimulate erythropoiesis. Among nonhematopoietic cell populations, IL-11, like IL-6 and LIF, can stimulate the synthesis of hepatic acute-phase proteins. Consistent with the in vitro functions of IL‑11, in vivo administration of rhIL-11 in normal mice was found to enhance the generation of Ig producing cells and platelets, and to increase the cycling rates of bone marrow-derived CFU-GM, BFU-E, and CFU-GEMM progenitors. IL-11 exerts its biological activities through binding to a specific high-affinity receptor complex consisting of an IL-11 receptor alpha chain and gp130.
Product Datasheets
Citations for Mouse IL-11 Biotinylated Antibody
R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.
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Citations: Showing 1 - 3
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IL11 antagonist inhibits uterine stromal differentiation, causing pregnancy failure in mice.
Authors: Menkhorst E, Salamonsen L, Robb L, Dimitriadis E
Biol. Reprod., 2009-01-14;80(5):920-7.
Species: Mouse
Sample Types: Serum
Applications: ELISA Development -
Interleukin 11 confers resistance to dextran sulfate sodium-induced colitis in mice
Authors: Takashi Nishina, Yutaka Deguchi, Mika Kawauchi, Chen Xiyu, Soh Yamazaki, Tetuo Mikami et al.
iScience
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Overexpression of IL-11 promotes premalignant gastric epithelial hyperplasia in isolation from germline gp130-JAK-STAT driver mutations
Authors: Jon N. Buzzelli, Louise O’Connor, Michelle Scurr, Sharleen Chung Nien Chin, Angelique Catubig, Garrett Z. Ng et al.
American Journal of Physiology-Gastrointestinal and Liver Physiology
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