Home / Integrin alpha 3/CD49c / Mouse Integrin  alpha 3/CD49c Antibody

Mouse Integrin  alpha 3/CD49c Antibody

Catalog #: AF2787
12 Citations 1 Review Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
AF2787
AF2787-SP
Product Details
Citations (12)
FAQs
Supplemental Products
Reviews (1)
Summary Preparation and Storage Reconstitution Calculator Background Product Datasheets Related Research Areas

Mouse Integrin  alpha 3/CD49c Antibody Summary

Species Reactivity
Mouse
Specificity
Detects mouse Integrin alpha 3/CD49c in direct ELISAs and Western blots. In direct ELISAs, less than 10% cross-reactivity with recombinant human (rh) Integrin alpha 3 is observed.
Source
Polyclonal Goat IgG
Purification
Antigen Affinity-purified
Immunogen
S. frugiperda insect ovarian cell line Sf 21-derived recombinant mouse Integrin alpha 3/CD49c
Phe33-Glu993
Accession # Q62470
Formulation
Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 µm filtered solution in PBS.
Label
Unconjugated

Applications

Recommended Concentration
Sample
Western Blot
0.1 µg/mL
Recombinant Mouse Integrin  alpha 3/CD49c
Flow Cytometry
0.25 µg/106 cells
XB2 mouse teratoma keratinocyte cell line
CyTOF-ready
Ready to be labeled using established conjugation methods. No BSA or other carrier proteins that could interfere with conjugation.
 

Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.

Reconstitution Calculator

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

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Preparation and Storage

Reconstitution
Reconstitute at 0.2 mg/mL in sterile PBS.
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Shipping
Lyophilized product is shipped at ambient temperature. Liquid small pack size (-SP) is shipped with polar packs. Upon receipt, store immediately at the temperature recommended below.
Stability & Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 6 months, -20 to -70 °C under sterile conditions after reconstitution.

Background: Integrin alpha 3/CD49c

Integrin alpha 3, also known as CD49c and VLA-3 alpha, is a type I membrane protein that heterodimerizes with Integrin beta 1. alpha 3 beta 1 is a cell surface adhesion molecule that functions as a receptor for laminin, fibronectin, collagen, epiligrin, thrombospondin and chondroitin sulfate proteoglycan 4. The extracellular domain of human and mouse Integrin alpha 3 share approximately 87% amino acid sequence homology.

Entrez Gene IDs
3675 (Human); 16400 (Mouse)
Alternate Names
antigen identified by monoclonal J143; CD49 antigen-like family member C; CD49c antigen; CD49c; FLJ34631; FLJ34704; FRP-2; Galactoprotein B3; GAP-B3; GAPB3CD49C; Integrin alpha 3; integrin alpha-3; integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor); ITGA3; MSK18; VCA-2; very late activation protein 3 receptor, alpha-3 subunit; VL3A; VLA-3 subunit alpha; VLA3a

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Citations for Mouse Integrin  alpha 3/CD49c Antibody

R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.

12 Citations: Showing 1 - 10
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  1. Integrin alpha 3 beta 1 in hair bulge stem cells modulates CCN2 expression and promotes skin tumorigenesis
    Authors: Veronika Ramovs, Ana Krotenberg Garcia, Ji-Ying Song, Iris de Rink, Maaike Kreft, Roel Goldschmeding et al.
    Life Science Alliance
  2. Uropod elongation is a common final step in leukocyte extravasation through inflamed vessels.
    Authors: Hyun YM, Sumagin R, Sarangi PP
    J. Exp. Med., 2012-06-18;209(7):1349-62.
  3. Integrin alpha 3 beta 1 regulates kidney collecting duct development via TRAF6-dependent K63-linked polyubiquitination of Akt
    Authors: Eugenia M. Yazlovitskaya, Hui-Yuan Tseng, Olga Viquez, Tianxiang Tu, Glenda Mernaugh, Karen K. McKee et al.
    Molecular Biology of the Cell
  4. The laminin binding alpha 3 and alpha 6 integrins cooperate to promote epithelial cell adhesion and growth
    Authors: Eugenia M. Yazlovitskaya, Olga M. Viquez, Tianxiang Tu, Adele De Arcangelis, Elisabeth Georges-Labouesse, Arnoud Sonnenberg et al.
    Matrix Biology
  5. Activated Protein C Attenuates Severe Inflammation by Targeting VLA-3(high) Neutrophil Subpopulation in Mice
    Authors: PP Sarangi, HW Lee, YV Lerman, A Trzeciak, EJ Harrower, AR Rezaie, M Kim
    J. Immunol., 2017-09-06;0(0):.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Flow Cytometry
  6. Integrin alpha6 maintains the structural integrity of the kidney collecting system
    Authors: Olga M Viquez
    Matrix Biol, 2016-12-30;0(0):.
    Species: Mouse
    Sample Types: Cell Lysates
    Applications: Western Blot
  7. Signaling events mediated by alpha3beta1 integrin are essential for mammary tumorigenesis.
    Authors: Cagnet S, Faraldo M, Kreft M, Sonnenberg A, Raymond K, Glukhova M
    Oncogene, 2013-09-30;33(34):4286-95.
    Species: Mouse
    Sample Types: Cell Lysates
    Applications: Western Blot
  8. Strain-induced differentiation of fetal type II epithelial cells is mediated via the integrin alpha6beta1-ADAM17/tumor necrosis factor-alpha-converting enzyme (TACE) signaling pathway.
    Authors: Wang Y, Huang Z, Nayak P, Matthews B, Warburton D, Shi W, Sanchez-Esteban J
    J Biol Chem, 2013-07-25;288(35):25646-57.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Neutralization
  9. Gain of glycosylation in integrin alpha3 causes lung disease and nephrotic syndrome.
    Authors: Nicolaou N, Margadant C, Kevelam S, Lilien M, Oosterveld M, Kreft M, van Eerde A, Pfundt R, Terhal P, van der Zwaag B, Nikkels P, Sachs N, Goldschmeding R, Knoers N, Renkema K, Sonnenberg A
    J Clin Invest, 2012-11-01;122(12):4375-87.
    Species: Mouse
    Sample Types: Cell Lysates
    Applications: Western Blot
  10. Integrin alpha3beta1 inhibits directional migration and wound re-epithelialization in the skin.
    Authors: Margadant C, Raymond K, Kreft M, Sachs N, Janssen H, Sonnenberg A
    J. Cell. Sci., 2009-01-15;122(0):278-88.
    Species: Mouse
    Sample Types: Cell Lysates
    Applications: Western Blot
  11. Hair follicle epidermal stem cells define a niche for tactile sensation
    Authors: Chun-Chun Cheng, Ko Tsutsui, Toru Taguchi, Noriko Sanzen, Asako Nakagawa, Kisa Kakiguchi et al.
    eLife
  12. Blood pressure influences end-stage renal disease of Cd151 knockout mice
    Authors: Norman Sachs, Nike Claessen, Jan Aten, Maaike Kreft, Gwendoline J.D. Teske, Anneke Koeman et al.
    Journal of Clinical Investigation

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Reviews for Mouse Integrin  alpha 3/CD49c Antibody

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Mouse Integrin  alpha 3/CD49c Antibody
By Anonymous on 12/07/2020
Application: MiAr Sample Tested: EDTA Plasma Species: Human

Antibody was printed on custom arrays and incubated with fluorescently labeled human EDTA plasma

Microarray Mouse Integrin  alpha 3/CD49c Antibody AF2787