Mouse Melanocortin-3 R/MC3R Antibody

Catalog #: MAB3737
1 Citation Datasheet / COA / SDS

Catalog #	Availability	Size / Price	Qty
MAB3737
MAB3737-SP

Product Details

Citations (1)

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Summary Preparation and Storage Reconstitution Calculator Background Product Datasheets Related Research Areas

Mouse Melanocortin-3 R/MC3R Antibody Summary

Species Reactivity

Mouse

Specificity

Detects Melanocortin 3R/MC3R in direct ELISAs and Western blots. Stains mouse Melanocortin 3R/MC3R-transfected cells but not irrelevant transfectants.

Source

Monoclonal Rat IgG_2A Clone # 345404

Purification

Protein A or G purified from hybridoma culture supernatant

Immunogen

Y3 rat myeloid cell line transfeced with mouse Melanocortin 3R/MC3R

Formulation

Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 µm filtered solution in PBS.

Label

Unconjugated

Applications

Recommended Concentration

Sample

Flow Cytometry

0.25 µg/10⁶ cells

Mouse Melanocortin 3R/MC3R transfected HEK293 cells

CyTOF-ready

Ready to be labeled using established conjugation methods. No BSA or other carrier proteins that could interfere with conjugation.

Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.

Reconstitution Calculator

Preparation and Storage

Reconstitution

Reconstitute at 0.5 mg/mL in sterile PBS.

Shipping

Lyophilized product is shipped at ambient temperature. Liquid small pack size (-SP) is shipped with polar packs. Upon receipt, store immediately at the temperature recommended below.

Stability & Storage

Use a manual defrost freezer and avoid repeated freeze-thaw cycles.

12 months from date of receipt, -20 to -70 °C as supplied.
1 month, 2 to 8 °C under sterile conditions after reconstitution.
6 months, -20 to -70 °C under sterile conditions after reconstitution.

Background: Melanocortin-3 R/MC3R

Mouse Melanocortin 3R (MC3R) is a member of the melanocortin receptor family. The 323 amino acid G-protein-coupled 7-transmembrane glycoprotein is expressed in the brain where, along with MC4R, it binds alpha, beta and gamma melanocyte stimulating hormones and is involved in regulating energy balance. MC3R is also expressed by macrophages and plays an anti-inflammatory role in the heart and other tissues. Of the 69 aa that are extracellular, mouse MC3R shares 91% and 78% sequence identity with rat and human MC3R, respectively.

Long Name

Melanocortin 3 Receptor

Entrez Gene IDs

4159 (Human); 17201 (Mouse); 29310 (Rat)

Alternate Names

BMIQ9; MC3; MC3R; MC3-R; melanocortin 3 receptor; melanocortin receptor 3; Melanocortin-3 R; Melanocortin3R; Melanocortin-3R; OB20; Obesity quantitative trait locus; OQTL

Product Datasheets

Product Datasheet

COA

SDS

Related Research Areas

Citation for Mouse Melanocortin-3 R/MC3R Antibody

R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.

1 Citation: Showing 1 - 1

ACTH treatment promotes murine cardiac allograft acceptance
Authors: J Zhao, L Jiang, M Uehara, N Banouni, BS Al Dulaija, J Azzi, T Ichimura, X Li, P Jarolim, P Fiorina, SG Tullius, JC Madsen, V Kasinath, R Abdi
JCI Insight, 2021-07-08;6(13):.
Species: Human
Sample Types: Whole Cells
Applications: IHC